Discovery and comparisons to Methanobrevibacter smithii
Originally isolated in 1994 from human dental plaque, Methanobrevibacter oralis has been the third most common methanogenic archaea seen in the human body, preceded by Methanobrevibacter smithii and Methanosphaera stadtmanae. This species of archaea has not been described in other species.[3] It has been seen in ancient human dental calculus, as well as in different studies of oral pathologies in different continents, from Europe, Asia, the Americas and Africa.[4][5]
The first draft genomic sequence, however, came from a strain that came from stool.[6] This species is highly phylogenetically related to M. smithii however it is not a distinct member of the human gut, instead it is most prevalent in the human oral cavity. Comparisons of their genomic sequences shows distinct gene differences between the two species that may provide some information on the niche distinction. Another difference that separates M. oralis from M. smithii is that it only utilizes hydrogen gas (H2) and carbon dioxide (CO2) for methanogenesis, while M. smithii uses those two substrates as well as formate.[7]
Implications in oral health and human microbiome
The major interest with M. oralis has been that it is associated with periodontal disease, with an increase in abundance seen of this archaea when compared to its abundance in healthy samples. Periodontitis is an infection caused by multiple, different anaerobic bacteria and it has been suggested that the increase of M. oralis contributes to this disease due to potential syntrophic interactions with the other members of this infection.[8][9] These syntrophic interactions include supporting microbial fermentation by consuming the hydrogen from said process. Although not currently considered a pathogen for this disease, multiple studies are looking into understanding its relation to this disease through more cultivation-independent sample sets, evolutionary studies, and immunological responses.[5][10]
Weyrich LS, Duchene S, Soubrier J, Arriola L, Llamas B, Breen J, Morris AG, Alt KW, Caramelli D, Dresely V, Farrell M, Farrer AG, Francken M, Gully N, Haak W, Hardy K, Harvati K, Held P, Holmes EC, Kaidonis J, Lalueza-Fox C, de la Rasilla M, Rosas A, Semal P, Soltysiak A, Townsend G, Usai D, Wahl J, Huson DH, Dobney K, Cooper A (April 2017). "Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus". Nature. 544 (7650): 357–361. doi:10.1038/nature21674. PMID28273061.
