Melena

Melena
Melena
Other names	Melaena, melæna
Pronunciation	/məˈliːnə/ or /ˈmɛlɪnə/ ;
Specialty	General surgery, gastroenterology
Symptoms	Dark blood in stool
Causes	Hemorrhoid; Gastritis; Gastrointestinal bleeding; Stomach cancer;

Melena is a form of blood in stool which refers to the dark black, tarry feces that are commonly associated with upper gastrointestinal bleeding.^[1] The black color and characteristic strong odor are caused by hemoglobin in the blood being altered by digestive enzymes and intestinal bacteria.^[2]

Iron supplements may cause a grayish-black stool that should be distinguished from melena,^[3] as should black coloration caused by a number of medications, such as bismuth subsalicylate (the active ingredient in Pepto-Bismol), or by foods such as beetroot, black liquorice, or blueberries.^[4]

Causes

The most common cause of melena is peptic ulcer disease.^[5] However, any bleeding within the upper gastrointestinal tract or the ascending colon can lead to melena.^[6] Melena may also be a complication of anticoagulant medications, such as warfarin.^[7]

Causes of upper gastrointestinal bleeding that may result in melena include malignant tumors affecting the esophagus, stomach or small intestine, hemorrhagic blood diseases, such as thrombocytopenia and hemophilia, gastritis, stomach cancer, esophageal varices, Meckel's diverticulum and Mallory-Weiss syndrome.^[8]

Causes of "false" melena include iron supplements, Pepto-Bismol, Maalox, and lead, blood swallowed as a result of a nose bleed (epistaxis), and blood ingested as part of the diet, as with consumption of black pudding (blood sausage), or with the traditional African Maasai diet, which includes much blood drained from cattle.^{[citation needed]}

Melena is considered a medical emergency as it arises from a significant amount of bleeding. Urgent care is required to rule out serious causes and prevent potentially life-threatening emergencies.

A less serious, self-limiting case of melena can occur in newborns two to three days after delivery, due to swallowed maternal blood.^{[citation needed]}

Diagnosis

In acute cases, with a large amount of blood loss, patients may present with anemia or low blood pressure. However, aside from the melena itself, many patients may present with few symptoms. Often, the first approach is to use endoscopy to look for obvious signs of a bleed. In cases where the source of the bleed is unclear, but melena is present, an upper endoscopy is recommended, to try to ascertain the source of the bleed.^{[citation needed]}

Lower gastrointestinal bleeding sources usually present with hematochezia or frank blood. A test with poor sensitivity/specificity that may detect the source of bleeding is the tagged red blood cell scan. This is especially used for slow bleeding (<0.5 ml/min). However, for rapid bleeding (>0.5 ml/min), mesenteric angiogram ± embolization is the gold standard. Colonoscopy is often first line, however.^{[citation needed]}

Melena versus hematochezia

Bleeds that originate from the lower gastrointestinal tract (such as the sigmoid colon and rectum) are generally associated with the passage of bright red blood, or hematochezia, particularly when brisk. Only blood that originates from a more proximal source (such as the small intestine), or bleeding from a lower source that occurs slowly enough to allow for enzymatic breakdown, is associated with melena. For this reason, melena is often associated with blood in the stomach or duodenum (upper gastrointestinal bleeding), for example by a peptic ulcer. A rough estimate is that it takes about 14 hours for blood to be broken down within the intestinal lumen; therefore if transit time is less than 14 hours the patient will have hematochezia, and if greater than 14 hours the patient will exhibit melena.^[8]^: 322 One often-stated rule of thumb is that melena only occurs if the source of bleeding is above the ligament of Treitz although, as noted below, exceptions occur with enough frequency to render it unreliable.^{[citation needed]}

Etymology

The origin of melena is dated to the early 19th century via modern Latin, via Greek melaina (feminine of melas, black).^{[citation needed]}

References

^ MedlinePlus Encyclopedia: Bloody or tarry stools, retrieved 19 July 2010.
^ Walker, Brian; Colledge, Nicki; Ralston, Stuart; Penman, Ian, eds. (2014). Davidson's Principles and Practice of Medicine (22nd ed.). Edinburgh: Churchill Livingstone. p. 854. ISBN 978-0-7020-5103-6.
^ Navarra, Tova (2004). The Encyclopædia of Vitamins, Minerals, and Supplements. Infobase Publishing. ISBN 9781438121031. Iron supplements cause a grayish-black stool that should be distinguished from the black, tarlike stool that occurs from bleeding ulcer.
^ Dugdale, David (2009-11-01). "Bloody or tarry stools". National Institutes of Health. Retrieved 2009-11-30.
^ Walker, HK; Hall, WD; Hurst, JW (1990). "Hematemesis, Melena, and Hematochezia". Clinical Methods: The History, Physical, and Laboratory Examinations. Butterworths. ISBN 9780409900774. Melena strongly suggests, and hematemesis confirms, that bleeding is of upper gastrointestinal origin…Peptic ulcer, the most common cause of gastrointestinal hemorrhage, should be pursued through questions about epigastric distress, the relationship of symptoms to food intake, and a history of peptic ulcer disease.
^ Talley, Nicholas; O'Connor, Simon (2014). Clinical Examination: A Systematic Guide To Physical Diagnosis (7th ed.). Chatswood: Churchill Livingstone. p. 179. ISBN 9780729541473.
^ Di Minno, Alessandro; Spadarella, Gaia; Spadarella, Emanuela; Tremoli, Elena; Di Minno, Giovanni (2015). "Gastrointestinal bleeding in patients receiving oral anticoagulation: Current treatment and pharmacological perspectives". Thrombosis Research. 136 (6): 1074–81. doi:10.1016/j.thromres.2015.10.016. PMID 26508464.
^ ^a ^b Laine, Loren (2012). "41. Gastrointestinal Bleeding". In Longo, Dan L; Fauci, Anthony S; Kasper, Dennis L; Hauser, Stephen L; Jameson, J. Larry; Loscalzo, Joseph (eds.). Harrison's principles of internal medicine (18th ed.). New York: McGraw-Hill. p. 320. ISBN 978-0-07-174889-6.