MAGED1

MAGED1
Identifiers
Aliases	MAGED1, DLXIN-1, NRAGE, MAGE family member D1
External IDs	OMIM: 300224; MGI: 1930187; HomoloGene: 5077; GeneCards: MAGED1; OMA:MAGED1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.22 Start 51,803,007 bp[1] End 51,902,354 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X C3|X 41.56 cM Start 93,579,080 bp[2] End 93,585,749 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone stromal cell of endometrium ganglionic eminence Pituitary Gland anterior pituitary tibia frontal pole middle temporal gyrus right adrenal cortex left adrenal cortex Top expressed in mandibular prominence median eminence maxillary prominence arcuate nucleus dorsomedial hypothalamic nucleus choroid plexus of fourth ventricle ventromedial nucleus islet of Langerhans Gonadal ridge hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding identical protein binding Cellular component cytoplasm nucleus membrane plasma membrane chromatin protein-containing complex Biological process rhythmic process regulation of circadian rhythm regulation of apoptotic process positive regulation of branching involved in ureteric bud morphogenesis regulation of transcription by RNA polymerase II positive regulation of apoptotic signaling pathway positive regulation of transcription, DNA-templated negative regulation of epithelial cell proliferation circadian regulation of gene expression regulation of transcription, DNA-templated positive regulation of MAP kinase activity negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9500 94275 Ensembl ENSG00000179222 ENSMUSG00000025151 UniProt Q9Y5V3 Q9QYH6 RefSeq (mRNA) NM_001005332 NM_001005333 NM_006986 NM_019791 RefSeq (protein) NP_001005332 NP_001005333 NP_008917 NP_062765 Location (UCSC) Chr X: 51.8 – 51.9 Mb Chr X: 93.58 – 93.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene.[5][6]

Function

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.[6]

MAGED was found to be deleted in a group of children with an intellectual disability disorder caused by a Xp11.22 deletion.[7]

Maged1 plays a role in controlling the reward circuitry in the brain of mice that is responsible for addictive behaviors.[8] More recently, it has been shown to play a role in drug addiction through an epigenetic mechanism involving the monoubiquitination of H2A, which represses gene expression via interaction with the deubiquitinase USP7.[9]

Interactions

MAGED1 has been shown to interact with UNC5A,[10] PJA1,[11] XIAP,[12] and USP7.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000179222 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025151 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Põld M, Zhou J, Chen GL, Hall JM, Vescio RA, Berenson JR (Sep 1999). "Identification of a new, unorthodox member of the MAGE gene family". Genomics. 59 (2): 161–7. doi:10.1006/geno.1999.5870. PMID 10409427.
6. "Entrez Gene: MAGED1 melanoma antigen family D, 1".
7. Grau C, Starkovich M, Azamian MS, Xia F, Cheung SW, Evans P, et al. (2017). "Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability". PLOS ONE. 12 (4): e0175962. Bibcode:2017PLoSO..1275962G. doi:10.1371/journal.pone.0175962. PMC 5393878. PMID 28414775.
8. De Backer JF, Monlezun S, Detraux B, Gazan A, Vanopdenbosch L, Cheron J, et al. (July 2018). "Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine". EMBO Reports. 19 (9): e45089. doi:10.15252/embr.201745089. PMC 6123657. PMID 30002119.*Lay summary in: "A gene required for addictive behavior". ScienceDaily. July 12, 2018.
9. Cheron J, Beccari L, Hagué P, Icick R, Despontin C, Carusone T, et al. (December 2023). "USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder". Nature Communications. 14 (1): 8481. doi:10.1038/s41467-023-44120-2. PMC 10733359. PMID 38123574.
10. Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
11. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (Jun 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
12. Jordan BW, Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, et al. (Oct 2001). "Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death". J. Biol. Chem. 276 (43): 39985–9. doi:10.1074/jbc.C100171200. PMID 11546791.

Further reading

• Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, et al. (2000). "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis". Neuron. 27 (2): 279–88. doi:10.1016/S0896-6273(00)00036-2. PMID 10985348.
• Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K (2001). "Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function". J. Biol. Chem. 276 (7): 5331–8. doi:10.1074/jbc.M008590200. PMID 11084035.
• Kubu CJ, Goldhawk DG, Barker PA, Verdi JM (2001). "Identification of the translational initiation codon in human MAGED1". Genomics. 70 (1): 150–2. doi:10.1006/geno.2000.6356. PMID 11087672.
• Zhang CG, Xing GC, Wei HD, Yu YT, He FC (2001). "[A new melanoma antigen-encoding gene subfamily in human chromosome X]". Yi Chuan Xue Bao. 28 (3): 197–203. PMID 11280991.
• Stone B, Schummer M, Paley PJ, Crawford M, Ford M, Urban N, et al. (2001). "MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily". Gene. 267 (2): 173–82. doi:10.1016/S0378-1119(01)00406-1. PMID 11313144.
• Jordan BW, Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, et al. (2001). "Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death". J. Biol. Chem. 276 (43): 39985–9. doi:10.1074/jbc.C100171200. PMID 11546791.
• Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
• Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
• Kendall SE, Goldhawk DE, Kubu C, Barker PA, Verdi JM (2003). "Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis". Mech. Dev. 117 (1–2): 187–200. doi:10.1016/S0925-4773(02)00204-6. PMID 12204258. S2CID 8919247.
• Williams ME, Strickland P, Watanabe K, Hinck L (2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
• Matsuda T, Suzuki H, Oishi I, Kani S, Kuroda Y, Komori T, et al. (2003). "The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution". J. Biol. Chem. 278 (31): 29057–64. doi:10.1074/jbc.M302199200. PMID 12754255.
• Wen CJ, Xue B, Qin WX, Yu M, Zhang MY, Zhao DH, et al. (2004). "hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation". FEBS Lett. 564 (1–2): 171–6. doi:10.1016/S0014-5793(04)00353-9. PMID 15094062. S2CID 39965080.
• Bertrand M, Huijbers I, Chomez P, De Backer O (2005). "Comparative expression analysis of the MAGED genes during embryogenesis and brain development". Dev. Dyn. 230 (2): 325–34. doi:10.1002/dvdy.20026. PMID 15162511.
• Tian XX, Rai D, Li J, Zou C, Bai Y, Wazer D, et al. (2005). "BRCA2 suppresses cell proliferation via stabilizing MAGE-D1". Cancer Res. 65 (11): 4747–53. doi:10.1158/0008-5472.CAN-05-0018. PMC 3295243. PMID 15930293.
• Xue B, Wen C, Shi Y, Zhao D, Li C (2005). "Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion". Biochem. Biophys. Res. Commun. 336 (1): 247–51. doi:10.1016/j.bbrc.2005.08.069. PMID 16125672.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.