Genoa has played 75 seasons in the Serie A, 34 seasons in the Serie B, and two seasons in the Serie C (or equivalent).
This list details the club's achievements in major competitions, and the top scorers for each season. Top scorers in bold were also the top scorers in the Italian league that season. Records of local or regional competitions are not included due to them being considered of less importance.
^Genoa was penalized with 28 points (10 of them to be served in the next season in 1960–61 Serie B, for a case of sporting fraud called The Cappello Case. Renato Ferrari (2 June 1960). "Un terrible monito". Corriere dello sport. p. 6. Archived from the original on 5 November 2013. Retrieved 28 February 2017.
^7 point penalty for the Capello case in the previous season.