Karla Satchell

Karla Satchell
Born
Karla Fullner

(1966-07-31) July 31, 1966 (age 58)
Anchorage, AK, U.S.
EducationPacific Lutheran University (BS)
University of Washington (PhD)
AwardsInvestigator in Pathogenesis of Infectious Disease, Burroughs Wellcome Fund (2006)
Driskill Graduate Program Dean's Outstanding Teacher Award, Northwestern Feinberg School of Medicine (2016)
Scientific career
FieldsMicrobiology
Structural biology
InstitutionsUniversity of Pittsburgh
Harvard Medical School
Northwestern University, Feinberg School of Medicine

Karla Satchell, (born Karla Fullner on July 31, 1966), is an American microbiologist who is currently the Anne Stewart Youman's Professor of Microbiology at Northwestern University Feinberg School of Medicine[1] and an elected fellow of the American Association for the Advancement of Science.[2] and the American Academy of Microbiology

Education

She earned her Ph.D at University of Washington in 1996 and conducted postdoctoral training with John Mekalanos at Harvard Medical School.[1]

Research

Her interests are microbiology, structural biology,[3] cytoskeleton, cellular microbiology, bacteria and diseases[4] and pathogenesis.[1] She is especially known for defining how the MARTX toxins of Vibrio cholerae and Vibrio vulnificus are modular proteins that deliver their constituent effectors to host cells to modify cell signaling to promote bacterial infection.[5]

Structural Biology

Satchell is head of the Center for Structural Biology of Infectious Diseases at Northwestern since 2017. The Center, established in 2007, provides an established consortium of laboratories in North America for rapid response research related to infectious disease outbreaks. The center determines 3-D structure of proteins from causing infectious such as bacteria, viruses and fungi to probe mechanisms of disease and inform strategies for effective diagnostics, vaccines and treatments.[6][7]

Publications

  • Kerri-Lynn Sheahan, Christina L. Cordero, and Karla J. Fullner Satchell. Identification of a domain within the multifunctional Vibrio cholerae RTX toxin that covalently cross-links actin. PNAS. vol. 101 no. 26. 9798–9803
  • KJF Satchell. MARTX, multifunctional autoprocessing repeats-in-toxin toxins. Infection and immunity. November 2007 vol. 75 no. 11 5079-5084.

Awards and honors

References

  1. ^ a b c "Karla Satchell". northwestern.edu. Retrieved December 27, 2017.
  2. ^ "Elected AAAS Fellows". northwestern.edu. December 13, 2016. Retrieved December 27, 2017.
  3. ^ "Lab". satchell-lab.com. Retrieved December 27, 2017.
  4. ^ "Karla Satchell". northwestern.edu. Retrieved December 27, 2017.
  5. ^ Satchell, Karla J. F. (25 June 2015). "Multifunctional-autoprocessing repeats-in-toxin (MARTX) Toxins of Vibrios". Microbiology Spectrum. 3 (3). doi:10.1128/microbiolspec.VE-0002-2014. PMC 4509488. PMID 26185092.
  6. ^ Rhodes, Dawn (January 24, 2020). "Northwestern University professor leading research team trying to stop coronavirus: 'We are here specifically for this.'". Chicago Tribune. Retrieved 2020-01-28.
  7. ^ Scudellari, Megan (19 May 2020). "The sprint to solve coronavirus protein structures — and disarm them with drugs". Nature. Retrieved 2 November 2021.
  8. ^ "Driskill Graduate Program Honors Students and Faculty". 12 September 2016.