John Thompson Shepherd (21 May 1919, Belfast, Ireland – 4 October 2011, Rochester, Minnesota) was a British-American cardiologist, medical researcher in cardiovascular physiology, and medical school dean.[1][2] His research on the regulation of the cardiovascular system included "classic studies on reflex control of the circulation, haemodynamic responses to heat stress and exercise, and mechanisms of vasodilation."[3]
Biography
After graduation from Belfast's Campbell College, John T. Shepherd studied medicine at Queen's University Belfast, qualifying M.B. and B.Ch. in 1945 and M.Ch. in 1948.[1] After completing his internship and residency at the Royal Victoria Hospital, Belfast,[3] he became a staff member of the department of the physiology of Queen's University, Belfast. There in 1951 he received the research medical degree of M.D.[1] He was awarded in 1953 a Fulbright Scholarship for one year to do cardiovascular research at the Mayo Clinic. He returned to Belfast in 1954 as a reader in physiology at Queen's University. In the department of physiology he had four close colleagues, namely Archibald David Mant Greenfield (1917–2005), Ian Campbell Roddie (1928–2011), Walter Ernest "Darty" Glover (1932–2017), and Robert Ford "Bob" Whelan (1922–1984), who later became deans of medical schools.[3] In 1956 Shepherd received a D.Sc. from Queen's University Belfast.[1] In 1957 he emigrated with his family to the United States and joined the staff of the Mayo Clinic, where he remained until his retirement in 1989.[3]
From 1966 to 1974 he was a professor and the chair of the department of physiology and biophysics with a joint appointment at the Mayo Medical School (now named the Mayo Clinic Alix School of Medicine) and the Mayo Graduate School of Medicine.[1]
He helped to train more than 100 research fellows. He was the author or co-author of several books and more than 300 scientific articles.[3]
Two of his brothers and five among his nephews and nieces became physicians. In 1945 he married Helen Mary Johnston, who died in 1987. They had a daughter, Gillian, and a son, Roger, both of whom became physicians.[1] Upon his death, John T. Shepherd was survived by his second wife, Marion, as well as his daughter and son from his first marriage, and "four step-children, five grandchildren, eight step-grandchildren and a great-grandson."[3]
Donald DE; Shepherd JT (1963). "Response to Exercise in Dogs with Cardiac Denervation". The American Journal of Physiology. 205 (2): 393–400. doi:10.1152/ajplegacy.1963.205.2.393. PMID14058123.
Strandell, Tore; Shepherd, John T. (2009). "The Effect in Humans of Increased Sympathetic Activity on the Blood Flow to Active Muscles". Acta Medica Scandinavica. 181: 146–167. doi:10.1111/j.0954-6820.1967.tb12622.x. PMID5231558.
Zitnik, Ralph S.; Burchell, Howard B.; Shepherd, John T. (1969). "Hemodynamic effects of inhalation of ammonia in man". The American Journal of Cardiology. 24 (2): 187–190. doi:10.1016/0002-9149(69)90402-0. PMID5799080.
Mancia, G.; Shepherd, J. T.; Donald, D. E. (1976). "Interplay among carotid sinus, cardiopulmonary, and carotid body reflexes in dogs". The American Journal of Physiology. 230 (1): 19–24. doi:10.1152/ajplegacy.1976.230.1.19. PMID1251904.
Donald, David E.; Shepherd, John T. (1979). "Cardiac receptors: Normal and disturbed function". The American Journal of Cardiology. 44 (5): 873–878. doi:10.1016/0002-9149(79)90216-9. PMID386768.
Cohen, Richard A.; Shepherd, John T.; Vanhoutte, Paul M. (1983). "Inhibitory Role of the Endothelium in the Response of Isolated Coronary Arteries to Platelets". Science. 221 (4607): 273–274. Bibcode:1983Sci...221..273C. doi:10.1126/science.6574604. PMID6574604.
Shepherd, J.; Katusic, Z. S.; Vedernikov, Y.; Vanhoutte, P. M. (1991). "Mechanisms of coronary vasospasm: Role of endothelium". Journal of Molecular and Cellular Cardiology. 23: 125–131. doi:10.1016/0022-2828(91)90031-G. PMID2038073.
Rowell, Loring G.; Shepherd, John T., eds. (1996). Exercise: regulation and integration of multiple systems. New York: Published for the American Physiological Society by Oxford University Press.
Shepherd, John T. (2003). Inside the Mayo clinic: a memoir. Afton, Minnesota: Afton Historical Society Press; foreword by Walter F. Mondale{{cite book}}: CS1 maint: postscript (link)
