Adjaye's research focuses on projects that are system biology-based nationally and internationally. He models human brain-(Nijmegen Breakage Syndrome, Bilirubin-induced neuronal damage and Alzheimer's disease) liver-NAFLD and kidney injury associated diseases using iPS cells (induced pluripotent stem cells).[4][8][9]
(contrib.) Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells., 2020;
(contrib.) IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network., 2020;
(contrib.) AP-2 amyloidogenesis reduces by promoting BACE1 trafficking and degradation in neurons., 2020;
(contrib.) Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant., 2018;
(contrib.) Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency., 2018;
(contrib.) Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain., 2020;
(contrib.) Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1., 2016;
(contrib.) Chromosomal Instability and Molecular Defects in Induced Pluripotent Stem Cells from Nijmegen Breakage Syndrome Patients., 2016;
(contrib.) Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks., 2016;
(contrib.) Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks., 2015.[4][9]
Personal life
Prof. James Adjaye is married to Mrs. Theresa Adjaye who is by profession a Clinical Pharmacist/ Independent Prescriber specialising in cardiovascular disease. Together, they have 4 children.
He is the elder brother of the British architect Sir. David Adjaye.[10]
^ abResearch, Director of the Institute for Stem Cell; Research, Regenerative MedicineProf Dr James Adjaye Institute for Stem Cell; Düsseldorf, Regenerative MedicineHeinrich-Heine-University Moorenstraße 5 40225. "Universität Düsseldorf: James Adjaye". www.neurosciences-duesseldorf.de. Retrieved 2022-03-07.{{cite web}}: CS1 maint: numeric names: authors list (link)