Iotroxic acid

Iotroxic acid

Clinical data
Trade names	Biliscopin, others
AHFS/Drugs.com	International Drug Names
ATC code	V08AC02 (WHO)
Identifiers
IUPAC name 3-{2-[2-(2-{[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]methoxy}ethoxy)ethoxy]acetamido}-2,4,6-triiodobenzoic acid
CAS Number	51022-74-3
PubChem CID	3740
DrugBank	DB08945
ChemSpider	3609
UNII	84C5PTP9X6
KEGG	D01388
ChEMBL	ChEMBL1651905
CompTox Dashboard (EPA)	DTXSID3048782
ECHA InfoCard	100.051.726
Chemical and physical data
Formula	C22H18I6N2O9
Molar mass	1215.818 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(Nc1c(I)c(c(I)cc1I)C(=O)O)COCCOCCOCC(=O)Nc2c(I)c(C(=O)O)c(I)cc2I

Iotroxic acid (trade name Biliscopin), used in the form of meglumine iotroxate, is a molecule used as a contrast medium during X-rays.[1][2] It is specifically used during tests looking at the gallbladder and biliary tract.[2] It is given by slow injection into a vein.[2]

Side effects are uncommon.[3] They include vomiting, skin flushing, headache, itchiness, and low blood pressure.[2] Rare side effects include seizures and allergic reactions.[2] It should not be used by those who have an iodine allergy.[2] Iotroxic acid is an iodine containing contrast media of the diionic dimer type.[4]

Iotroxic acid was first made in 1976.[5] It is on the World Health Organization's List of Essential Medicines.[6] It is rarely used in the developed world due to the availability of magnetic resonance cholangiopancreatography (MRCP).[7]

References

1. "Iotroxic Acid". Drugs.com. Archived from the original on 31 December 2016. Retrieved 31 December 2016.
2. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 315, 318. hdl:10665/44053. ISBN 9789241547659.
3. Neugebauer E, Sauerland S (2014). "Diagnosis and treatment of common bile duct stones". Recommendations for evidence-based endoscopic surgery: The updated EAES consensus development conferences. Springer Science & Business Media. p. 67. ISBN 9782817808499. Archived from the original on 2017-01-01.
4. Schaefer C, Peters PW, Miller RK (2014). "Iodine containing contrast media". Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment. Academic Press. p. 532. ISBN 9780124079014. Archived from the original on 2017-01-01.
5. Korolkovas A (1988). Essentials of Medicinal Chemistry. Wiley. p. 1063. ISBN 9780471883562. Archived from the original on 2017-01-01.
6. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
7. Sherlock S, Dooley J (2008). "Imaging of the Biliary Tract: Interventional Radiology and Endoscopy". Diseases of the Liver and Biliary System. John Wiley & Sons. p. 568. ISBN 9780470986813. Archived from the original on 2017-01-01.