Interleukin 12 receptor, beta 2 subunit

IL12RB2
Identifiers
Aliases	IL12RB2, Interleukin 12 receptor, beta 2 subunit, interleukin 12 receptor subunit beta 2
External IDs	OMIM: 601642; MGI: 1270861; HomoloGene: 1197; GeneCards: IL12RB2; OMA:IL12RB2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 67,307,364 bp[1] End 67,398,724 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C1|6 30.81 cM Start 67,268,302 bp[2] End 67,353,172 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle testicle body of pancreas Achilles tendon prefrontal cortex gonad granulocyte lymph node cingulate gyrus Top expressed in zygote secondary oocyte gray matter layer of cerebellum morula blastocyst thymus neural layer of retina primary oocyte muscle of thigh striated muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity protein kinase binding cytokine binding Cellular component integral component of membrane external side of plasma membrane integral component of plasma membrane plasma membrane membrane receptor complex Biological process response to lipopolysaccharide cell surface receptor signaling pathway positive regulation of cell population proliferation positive regulation of interferon-gamma production peptidyl-tyrosine phosphorylation response to cytokine interleukin-12-mediated signaling pathway interleukin-35-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3595 16162 Ensembl ENSG00000081985 ENSMUSG00000018341 UniProt Q99665 P97378 RefSeq (mRNA) NM_001258214 NM_001258215 NM_001258216 NM_001559 NM_001319233 NM_001374259 NM_008354 NM_001311141 RefSeq (protein) NP_001245143 NP_001245144 NP_001245145 NP_001306162 NP_001550 NP_001361188 NP_001298070 NP_032380 Location (UCSC) Chr 1: 67.31 – 67.4 Mb Chr 6: 67.27 – 67.35 Mb PubMed search [3] [4]
Wikidata
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Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.[5] IL12RB2 orthologs[6] have been identified in all mammals for which complete genome data are available.

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.[7] The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.[5]

Interactions

Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2.[8]

RNA editing

The mRNA of this protein is subject to RNA editing.

References

1. GRCh38: Ensembl release 89: ENSG00000081985 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018341 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2".
6. "OrthoMaM phylogenetic marker: IL12RB2 coding sequence".^[permanent dead link‍]
7. Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ (September 2012). "T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2". Immunity. 37 (3): 501–10. doi:10.1016/j.immuni.2012.05.031. PMC 3501343. PMID 22960221.
8. Yamamoto K, Shibata F, Miura O, Kamiyama R, Hirosawa S, Miyasaka N (April 1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus". Biochem. Biophys. Res. Commun. 257 (2). UNITED STATES: 400–4. doi:10.1006/bbrc.1999.0479. ISSN 0006-291X. PMID 10198225.

Further reading

• Airoldi I, Guglielmino R, Carra G, et al. (2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): 434–42. PMID 11940489.
• Chua AO, Chizzonite R, Desai BB, et al. (1994). "Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130". J. Immunol. 153 (1): 128–36. doi:10.4049/jimmunol.153.1.128. PMID 7911493. S2CID 9211163.
• Andrew SE, Goldberg YP, Kremer B, et al. (1993). "The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease". Nat. Genet. 4 (4): 398–403. doi:10.1038/ng0893-398. PMID 8401589. S2CID 20645822.
• Presky DH, Yang H, Minetti LJ, et al. (1997). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002–7. Bibcode:1996PNAS...9314002P. doi:10.1073/pnas.93.24.14002. PMC 19484. PMID 8943050.
• Zou J, Presky DH, Wu CY, Gubler U (1997). "Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases". J. Biol. Chem. 272 (9): 6073–7. doi:10.1074/jbc.272.9.6073. PMID 9038232.
• Rogge L, Barberis-Maino L, Biffi M, et al. (1997). "Selective expression of an interleukin-12 receptor component by human T helper 1 cells". J. Exp. Med. 185 (5): 825–31. doi:10.1084/jem.185.5.825. PMC 2196163. PMID 9120388.
• Yamamoto K, Kobayashi H, Miura O, et al. (1997). "Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization". Cytogenet. Cell Genet. 77 (3–4): 257–8. doi:10.1159/000134589. PMID 9284929.
• Presky DH, Minetti LJ, Gillessen S, et al. (1998). "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex". J. Immunol. 160 (5): 2174–9. doi:10.4049/jimmunol.160.5.2174. PMID 9498755.
• Morton SM, Bocaccio I, Depetris D, et al. (1998). "Assignment of IL12RB2 to human chromosome 1p31.3→p31.2 between D1S230 and D1S198". Cytogenet. Cell Genet. 79 (3–4): 282–3. doi:10.1159/000134743. PMID 9605872.
• Naeger LK, McKinney J, Salvekar A, Hoey T (1999). "Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling". J. Biol. Chem. 274 (4): 1875–8. doi:10.1074/jbc.274.4.1875. PMID 9890938.
• Yamamoto K, Shibata F, Miura O, et al. (1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus". Biochem. Biophys. Res. Commun. 257 (2): 400–4. doi:10.1006/bbrc.1999.0479. PMID 10198225.
• Yao BB, Niu P, Surowy CS, Faltynek CR (1999). "Direct interaction of STAT4 with the IL-12 receptor". Arch. Biochem. Biophys. 368 (1): 147–55. doi:10.1006/abbi.1999.1302. PMID 10415122.
• Matsui E, Kaneko H, Fukao T, et al. (2000). "Mutations of the IL-12 receptor beta2 chain gene in atopic subjects". Biochem. Biophys. Res. Commun. 266 (2): 551–5. doi:10.1006/bbrc.1999.1859. PMID 10600539.
• van Rietschoten JG, Smits HH, Westland R, et al. (2000). "Genomic organization of the human interleukin-12 receptor beta2-chain gene". Immunogenetics. 51 (1): 30–6. doi:10.1007/s002510050005. PMID 10663559. S2CID 25756200.
• van Rietschoten JG, Smits HH, van de Wetering D, et al. (2001). "Silencer activity of NFATc2 in the interleukin-12 receptor beta 2 proximal promoter in human T helper cells". J. Biol. Chem. 276 (37): 34509–16. doi:10.1074/jbc.M102536200. PMID 11438525.
• Kim J, Uyemura K, Van Dyke MK, et al. (2001). "A role for IL-12 receptor expression and signal transduction in host defense in leprosy". J. Immunol. 167 (2): 779–86. doi:10.4049/jimmunol.167.2.779. PMID 11441083.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jones ML, Young JM, Huang QR, et al. (2003). "Interleukin 12-augmented T cell proliferation of peripheral blood mononuclear cells from HIV-seropositive individuals is associated with interleukin 12 receptor beta 2 upregulation". AIDS Res. Hum. Retroviruses. 19 (4): 283–92. doi:10.1089/088922203764969483. PMID 12804004.
• Yamamoto K, Yamaguchi M, Miyasaka N, Miura O (2003). "SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit". Biochem. Biophys. Res. Commun. 310 (4): 1188–93. doi:10.1016/j.bbrc.2003.09.140. PMID 14559241.