Hol-Tox family

The putative holin-like toxin (Hol-Tox) family (TC# 1.E.42) consists of many small proteins, between 34 and 48 amino acyl residues (aas) with a single transmembrane segment (TMSs). Rajesh et al. (2011) first identified the gene and designated it tmp1, which coded for a 34 amino acyl peptide that acts as an antibacterial agent on gram-positive bacteria.[1] This peptide exhibits a single transmembrane domain (TMD) that is believed to play a role in facilitating the antibacterial activity.[1] A representative list of proteins belonging to the Hol-Tox family can be found in the Transporter Classification Database.[2]

See also

• Holin
• Lysin

Further reading

• Reddy, Bhaskara L.; Saier Jr, Milton H. (2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.
• Saier, Milton H.; Reddy, Bhaskara L. (2015). "Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications". Journal of Bacteriology. 197 (1): 7–17. doi:10.1128/JB.02046-14. PMC 4288690. PMID 25157079.
• Wang, I. N.; Smith, D. L.; Young, R. (2000). "Holins: the protein clocks of bacteriophage infections". Annual Review of Microbiology. 54: 799–825. doi:10.1146/annurev.micro.54.1.799. PMID 11018145.
• Young, R.; Bläsi, U. (1995). "Holins: form and function in bacteriophage lysis". FEMS Microbiology Reviews. 17 (1–2): 191–205. doi:10.1111/j.1574-6976.1995.tb00202.x. PMID 7669346.

References

1. Rajesh, Thangamani; Anthony, Thangamani; Saranya, Subramani; Pushpam, Paul Lavanya; Gunasekaran, Paramasamy (2011-02-01). "Functional characterization of a new holin-like antibacterial protein coding gene tmp1 from goat skin surface metagenome". Applied Microbiology and Biotechnology. 89 (4): 1061–1073. doi:10.1007/s00253-010-2907-6. ISSN 1432-0614. PMID 20927512. S2CID 9315098.
2. "1.E.42 The Putative Holin-like Toxin (Hol-Tox) Family". TCDB. Retrieved 2016-03-28.

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