Manfredi debuted as a singer-songwriter in 1972 with La crisi, an album filled with political and social themes.[1][2] In 1973 he started working at the Italian Institute of History of Philosophy. Since 1974 he was also active as a songwriter for other artists, including Mia Martini, Mina, PFM, Wess & Dori Ghezzi, Drupi, Heather Parisi, Donatello.[2][1]
Starting from the early 1980s Manfredi almost completely abandoned the music to focus on writing. He then published over a dozen novels and short stories, collaborated in various roles to several films, TV-series and plays, and created several comic series.[2][1] He was also active as a musical critic and wrote essays on Adriano Celentano, Lucio Battisti, Enzo Jannacci and other Italian music artists.[2][1]
Manfredi lived with his wife Mirella in Italy. His first daughter Diana Manfredi is a film director. He died on 24 January 2025, at the age of 76.[3]
