GVD (chemotherapy)

GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]

The GVD regimen consists of three drugs, from which its name is derived:

1. Gemcitabine;
2. Vinorelbine; and
3. Doxil, a pegylated liposomal formulation of doxorubicin.

Dosing

Drug	Dose in transplant-naive patients	Dose in post-transplant patients	Mode	Days
Gemcitabine	1000 mg/m^2	800 mg/m^2	IV infusion	Days 1, 8
Vinorelbine	20 mg/m^2	15 mg/m^2	IV bolus	Days 1, 8
Doxil	15 mg/m^2	10 mg/m^2	IV infusion	Days 1, 8

Repeated every 21 days (3 weeks).

References

1. Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804