G6B

MPIG6B
Identifiers
Aliases	MPIG6B, G6b, NG31, C6orf25, G6B, chromosome 6 open reading frame 25, G6b-B, megakaryocyte and platelet inhibitory receptor G6b, THAMY
External IDs	OMIM: 606520; MGI: 2146995; HomoloGene: 82249; GeneCards: MPIG6B; OMA:MPIG6B - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,718,594 bp[1] End 31,726,714 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,281,669 bp[2] End 35,285,160 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte bone marrow cells skin of leg skin of abdomen testicle right lung epithelium of colon spleen Top expressed in bone marrow spleen embryo blastocyst lip morula ventricle of the heart testicle epiblast zone of skin More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding protein binding Cellular component integral component of membrane plasma membrane endoplasmic reticulum membrane Golgi apparatus Biological process platelet activation negative regulation of signal transduction integrin-mediated signaling pathway blood coagulation erythrocyte differentiation megakaryocyte differentiation platelet formation megakaryocyte development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80739 106722 Ensembl ENSG00000206396 ENSG00000224393 ENSG00000204420 ENSG00000237459 ENSG00000230060 ENSG00000228090 ENSG00000231003 ENSMUSG00000073414 UniProt O95866 D7PDD4 RefSeq (mRNA) NM_025260 NM_138272 NM_138273 NM_138274 NM_138275 NM_138276 NM_138277 NM_001033221 NM_001191012 RefSeq (protein) NP_079536 NP_612116 NP_612117 NP_612118 NP_612119 NP_612121 NP_079536.2 NP_612116.1 NP_612117.1 NP_612118.1 NP_612119.1 NP_612121.1 NP_001028393 NP_001177941 Location (UCSC) Chr 6: 31.72 – 31.73 Mb Chr 17: 35.28 – 35.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein G6b is a protein that in humans is encoded by the G6B gene, or C6orf25.[5][6][7]

This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

References

1. ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 GRCh38: Ensembl release 89: ENSG00000206396, ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073414 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (Jul 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol. 163 (1): 278–87. doi:10.4049/jimmunol.163.1.278. PMID 10384126.
6. de Vet EC, Aguado B, Campbell RD (Nov 2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253.
7. "Entrez Gene: C6orf25 chromosome 6 open reading frame 25".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• de Vet EC, Newland SA, Lyons PA, et al. (2005). "The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin". FEBS Lett. 579 (11): 2355–8. Bibcode:2005FEBSL.579.2355D. doi:10.1016/j.febslet.2005.03.032. PMID 15848171. S2CID 24445026.
• Newland SA, Macaulay IC, Floto AR, et al. (2007). "The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro". Blood. 109 (11): 4806–9. doi:10.1182/blood-2006-09-047449. PMID 17311996.
• Li J, Cadeiras M, Prinz von Bayern M, et al. (2007). "G6b-B cell surface inhibitory receptor expression is highly restricted to CD4+ T-cells and induced by interleukin-4-activated STAT6 pathway". Hum. Immunol. 68 (8): 708–14. doi:10.1016/j.humimm.2007.04.008. PMID 17678728.