Calderón's senior career began with Unión Santa Fe.[1][3][4] He previously had youth stints with Charata Juniors and Cooperativista.[5][6]Leonardo Madelón moved the defender into the first-team set-up in 2018–19, subsequently selecting Calderón to start a Copa de la Superliga first round, first leg at the Estadio La Ciudadela on 13 April 2019; he appeared for the full duration of a 1–1 draw.[1][7] By the conclusion of 2019–20, Calderón had made thirteen appearances in all competitions for Unión; a period in which he scored his first goal, netting in a Copa Argentina first round defeat to Primera C Metropolitana's Dock Sud.[1]