FGF20

fibroblast growth factor 20
Identifiers
SymbolFGF20
NCBI gene26281
HGNC3677
OMIM605558
RefSeqNM_019851
UniProtQ9NP95
Other data
LocusChr. 8 p22
Search for
StructuresSwiss-model
DomainsInterPro

Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene.[1]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development,[2] cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be expressed in normal brain, particularly the cerebellum. The rat homolog is preferentially expressed in the brain and able to enhance the survival of midbrain dopaminergic neurons in vitro.[3]

References

  1. ^ Kirikoshi H, Sagara N, Saitoh T, Tanaka K, Sekihara H, Shiokawa K, Katoh M (August 2000). "Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22". Biochemical and Biophysical Research Communications. 274 (2): 337–43. doi:10.1006/bbrc.2000.3142. PMID 10913340.
  2. ^ Koga C, Adati N, Nakata K, Mikoshiba K, Furuhata Y, Sato S, Tei H, Sakaki Y, Kurokawa T (August 1999). "Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis". Biochemical and Biophysical Research Communications. 261 (3): 756–65. doi:10.1006/bbrc.1999.1039. PMID 10441498.
  3. ^ "Entrez Gene: Fibroblast growth factor 20".


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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