Ethambutol/isoniazid/pyrazinamide/rifampicin

Ethambutol/isoniazid/pyrazinamide/rifampicin

Combination of
Ethambutol	Anti-tuberculosis medication
Isoniazid	Anti-tuberculosis medication
Pyrazinamide	Anti-tuberculosis medication
Rifampicin	Anti-tuberculosis medication
Clinical data
Trade names	Voractiv, Rimstar, others
Routes of administration	By mouth
ATC code	J04AM06 (WHO)
Identifiers
CAS Number	357397-87-6
ChemSpider	none

Ethambutol/isoniazid/pyrazinamide/rifampicin, also known as ethambutol/isoniazid/pyrazinamide/rifampin, is a medication used for tuberculosis.[1] It is a fixed dose combination of ethambutol, isoniazid, pyrazinamide, and rifampicin.[1] It is used either alone or with other antituberculosis medication.[1] It is taken by mouth.[1]

Side effects are those of the underlying medications.[1] Pyridoxine may be used to decrease the risk of numbness.[2] It is not recommended in people with liver problems or severe kidney problems.[3] Use may not be suitable in children.[1] It is unclear if use during pregnancy is safe.[3]

It is on the World Health Organization's List of Essential Medicines.[4] It is sold under the brand names Voractiv and Rimstar in the UK.[3]

References

1. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 142. hdl:10665/44053. ISBN 9789241547659.
2. British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.
3. "Rimstar Film-coated Tablet / Voractiv Film-coated Tablet - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. February 2016. Archived from the original on 20 December 2016. Retrieved 18 December 2016.
4. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

External links

• "Ethambutol mixture with Isoniazid". Drug Information Portal. U.S. National Library of Medicine.
• "Isoniazid mixture with Rifampin". Drug Information Portal. U.S. National Library of Medicine.
• "Pyrazinamide". Drug Information Portal. U.S. National Library of Medicine.