Dimitri Kullmann

Dimitri Kullmann FRS FMedSci MAE
Kullmann in 2018
Born	Dimitri Michael Kullmann 1958 (age 66–67)[4] London, England[4]
Education	Lycée Français Charles de Gaulle[4]
Alma mater	University of Oxford
Awards	Baly Medal (2017)[1]
Scientific career
Fields	Neuroscience[2] Synaptic transmission[2] Channelopathies[2] Epilepsy[2]
Institutions	University College London University of California, San Francisco[1] National Hospital for Neurology and Neurosurgery UCL Institute of Neurology
Thesis	Central actions of muscle receptors (1984)
Doctoral advisor	Julian Jack[3]
Website	www.ucl.ac.uk/ion/research/synaptopathies/principal-investigators/dimitri-m-kullmann

Dimitri Michael Kullmann (born 1958)[4] is a British neurologist who is a professor of neurology at the UCL Institute of Neurology,[1] University College London (UCL), and leads the synaptopathies initiative funded by the Wellcome Trust.[5] Kullmann is a member of the Queen Square Institute of Neurology Department of Clinical and Experimental Epilepsy[6] and a consultant neurologist at the National Hospital for Neurology and Neurosurgery.[2][7]

Education

Kullmann was educated at the Lycée Français Charles de Gaulle[4] and studied physiology at Balliol College, Oxford[4] where he was awarded a Bachelor of Arts (BA) degree and a Doctor of Philosophy degree.[3] He studied and trained at the University of Oxford and St Thomas's Hospital Medical School at the University of London.[1] His postgraduate research was supervised by Julian Jack.[3]

Research and career

Kullmann's research[2][7] investigates how synapses function in health and disease.[8] His laboratory helped to show how neurotransmitters activate different receptor subtypes in and around synapses, and resolved some controversies about the mechanisms of long-term changes in synaptic strength.[8] Genetic and autoimmune disorders of synaptic proteins (‘synaptopathies’) provide insights into the mechanisms of a broad range of neurological diseases including epilepsy and migraine.[8] Together with his colleagues, Kullmann has used these insights to devise gene therapy strategies that could be used to treat intractable epilepsy.[8][2]

The Kullmann lab[2][7] has contributed to the discovery and elucidation of silent synapses,[9] glutamate spillover, tonic inhibition,[10] long-term potentiation in interneurons,[11] neurological channelopathies[12] and Synaptopathies, gene therapy for epilepsy,[13] and mechanisms of neural oscillations.[14] Kullmann served as the editor-in-chief of the scientific journal Brain between 2014 and 2020[15] and is on the editorial board of the journal Neuron.[16] Before working at UCL, he did postdoctoral research with Roger Nicoll at the University of California, San Francisco.[1]

Awards and honours

Kullmann was awarded the University Gold Medal in Medicine by the University of London, in 1986.[1] and the Baly Medal by the Royal College of Physicians in 2017.[1] He was elected a Guarantor of Brain in 2000,[17] elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2001,[18] a Corresponding Fellow of the American Neurological Association in 2013,[19] a member of the Academia Europaea (MAE) in 2017[20] and a Fellow of the Royal Society (FRS) in 2018.[8] He was awarded the 2023 Basic Science Research Award by the American Epilepsy Society.[21]

References

1. "Prof Dimitri Michael Kullmann: Iris View Profile". University College London. Retrieved 2 October 2016.
2. Dimitri Kullmann publications indexed by Google Scholar
3. Kullman, Dimitri Michael (1984). Central actions of muscle receptors (DPhil thesis). University of Oxford. OCLC 59330270. EThOS uk.bl.ethos.353099. Archived from the original on 16 December 2019. Retrieved 6 June 2018.
4. Anon (2019). "Kullmann, Prof. Dimitri Michael". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. (Subscription or UK public library membership required.)
5. "Synaptopathies". University College London. 17 July 2014. Retrieved 2 October 2016.
6. "DCEE". University College London. 29 May 2020. Retrieved 7 June 2021.
7. Dimitri Kullmann publications from Europe PubMed Central
8. Anon (2018). "Professor Dimitri Kullmann FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 May 2018. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

   "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)

9. Kullmann, Dimitri M. (1994). "Amplitude fluctuations of". Neuron. 12 (5): 1111–1120. doi:10.1016/0896-6273(94)90318-2. PMID 7910467. S2CID 54357872.
10. Semyanov, Alexey; Walker, Matthew C.; Kullmann, Dimitri M.; Silver, R.Angus (2004). "Tonically active GABAA receptors: modulating gain and maintaining the tone". Trends in Neurosciences. 27 (5): 262–269. doi:10.1016/j.tins.2004.03.005. ISSN 0166-2236. PMID 15111008. S2CID 2660172.
11. Lamsa, Karri P.; Heeroma, Joost H.; Somogyi, Peter; Rusakov, Dmitri A.; Kullmann, Dimitri M. (2007). "Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit". Science. 315 (5816): 1262–1266. Bibcode:2007Sci...315.1262L. doi:10.1126/science.1137450. ISSN 1095-9203. PMC 3369266. PMID 17332410.
12. Kullmann, Dimitri M. (2010). "Neurological channelopathies". Annual Review of Neuroscience. 33: 151–172. doi:10.1146/annurev-neuro-060909-153122. ISSN 1545-4126. PMID 20331364.
13. Wykes, Robert C.; Heeroma, Joost H.; Mantoan, Laura; Zheng, Kaiyu; MacDonald, Douglas C.; Deisseroth, Karl; Hashemi, Kevan S.; Walker, Matthew C.; Schorge, Stephanie (2012). "Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy". Science Translational Medicine. 4 (161): 161ra152. doi:10.1126/scitranslmed.3004190. ISSN 1946-6242. PMC 3605784. PMID 23147003.
14. Akam, Thomas; Oren, Iris; Mantoan, Laura; Ferenczi, Emily; Kullmann, Dimitri M. (2012). "Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling". Nature Neuroscience. 15 (5): 763–768. doi:10.1038/nn.3081. ISSN 1546-1726. PMC 3378654. PMID 22466505.
15. "Editorial board | Brain". Brain.oxfordjournals.org. 26 September 2016. Archived from the original on 11 October 2014. Retrieved 2 October 2016.
16. "Editorial Board: Neuron". cell.com.
17. "Guarantors of Brain". Guarantors of Brain. Retrieved 11 August 2016.
18. "Professor Dimitri Kullmann FMedSci". acmedsci.ac.uk. Retrieved 2 October 2016.
19. "American Neurological Association (ANA)". Myana.org. Retrieved 1 November 2016.
20. Hoffmann, Ilire Hasani, Robert. "Academy of Europe: Kullmann Dimitri". ae-info.org.
21. "Dimitri M. Kullmann, D.Phil., FRS, FMedSci, MAE, Receives the 2023 Basic Science Research Award".

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