Dawn Bowdish

Dawn M. E. Bowdish
Born	(1976-05-21) May 21, 1976 (age 48) Hamilton, Canada
Alma mater	University of British Columbia, Vancouver University of Oxford, England
Scientific career
Fields	Biology Immunology Aging
Institutions	McMaster University
Academic advisors	Lori Burrows Joe Lam Robert E. W. Hancock Siamon Gordon

Dawn M. E. Bowdish, (born May 21, 1976) is a Canadian immunologist and currently a professor in the Department of Pathology and Molecular Medicine at McMaster University in Ontario, Canada.

Career

In 1999, she graduated from the University of Guelph with an Honours Bachelor of Science in microbiology. Bowdish obtained her PhD from the University of British Columbia in 2005.[1] There, under the supervision of Robert E. W. Hancock, she discovered the immunomodulatory role of the host defence peptide LL-37.[2][3][4][5] Bowdish worked at the University of Oxford from 2005-2008 under the supervision of Siamon Gordon where she studied the role of MARCO in eliciting an immune response Mycobacterium tuberculosis.[1][6]

Bowdish was appointed to the Department of Pathology & Molecular Medicine at McMaster University in 2009. Since, Bowdish has uncovered how aging alters myeloid cells to increase susceptibility to pneumococcal pneumonia,[7][8] and demonstrated that age-associated gut microbe dysbiosis in mice increases age-associated inflammation.[9]

References

1. "Keeping grandparents and grandchildren together for as long as possible". Retrieved 2024-09-16.
2. Bowdish D. M., Davidson D. J., Speert D. P., Hancock R. E. (2004). "The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes". Journal of Immunology. 172 (6): 3758–65. doi:10.4049/jimmunol.172.6.3758. PMID 15004180.
3. Bowdish D.M., Davidson D. J., Lau Y.E., Lee K., Scott M. G., Hancock R. E. (2005). "Impact of LL-37 on anti-infective immunity". Journal of Leukocyte Biology. 77 (4): 451–9. doi:10.1189/jlb.0704380. PMID 15569695.
4. Bowdish D.M., Davidson D.J., Hancock R.E. (2005). "A re-evaluation of the role of host defence peptides in mammalian immunity". Current Protein & Peptide Science. 6 (1): 35–51. doi:10.2174/1389203053027494. PMID 15638767.
5. Bowdish D. M., Davidson D. J., Scott M. G., Hancock R. E. (2005). "Immunomodulatory activities of small host defense peptides". Antimicrobial Agents and Chemotherapy. 49 (5): 1727–32. doi:10.1128/AAC.49.5.1727-1732.2005. PMC 1087655. PMID 15855488.
6. Bowdish D.M., Sakamoto K., Kim M. J., Kroos M., Mukhopadhyay S., Leifer C. A., Tryggvason K., Gordon S., Russell D. G. (2009). "MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis". PLOS Pathogens. 5 (6): e1000474. doi:10.1371/journal.ppat.1000474. PMC 2688075. PMID 19521507.
7. Verschoor C. P., Johnstone J., Loeb M., Bramson J. L., Bowdish D. M. (2014). "Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling". Human Immunology. 75 (12): 1192–6. doi:10.1016/j.humimm.2014.10.004. PMID 25446401.
8. Verschoor C.P., Johnstone J., Millar J., Parsons R., Lelic A., Loeb M., Bramson J. L., Bowdish D. M. (2014). "Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly". PLOS ONE. 9 (8): e104522. Bibcode:2014PLoSO...9j4522V. doi:10.1371/journal.pone.0104522. PMC 4126708. PMID 25105870.
9. Thevaranjan N., Puchta A., Schulz C., Naidoo A., Szamosi J. C., Verschoor C. P., Loukov D., Schenck L. P., Jury J., Foley K. P., Schertzer J. D., Larché M. J., Davidson D. J., Verdú E. F., Surette M. G., Bowdish D. M. E. (2017). "Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction". Cell Host & Microbe. 21 (4): 455–466. doi:10.1016/j.chom.2017.03.002. PMC 5392495. PMID 28407483.

External links

• Bowdish Lab - Macrophage Biology at McMaster University
• Dawn Bowdish publications indexed by Google Scholar