Daniel Mansuy graduated from the École nationale supérieure de chimie de Paris (now Chimie Paris Tech) in 1967 and obtained a doctorate in science from the Université Pierre-et-Marie-Curie in 1970 under the supervision of Marc Julia.[2] He then joined the CNRS as a research manager and then director of research in 1992. He was co-founder in 1984 and director (1984-1996 and 1999-2005) of the Laboratory of Pharmaceutical and Toxicological Chemistry and Biochemistry at Paris Descartes University.[3] He is currently Director of Research Emeritus Outstanding Class.
Scientific work
Structure of Fe(TPP)C2(C6H4Cl)2, one of several iron carbenoid complexes prepared by Mansuy (TPP = conjugate base of tetraphenylporphyrin).[4]
Daniel Mansuy is particularly interested in phenomena at the interface between chemistry and biology, and in particular in the chemistry and pharmacochemistry of cytochromes P450. His work has led to the discovery of a new class of carbene and nitreneiron complexes[5] and of one of the first catalytic systems of nitrene transfer to alkanes and alkenes. He has also developed new catalysts for the oxidation of alkanes, alkenes and aromatics, used to predict drug metabolism and in the field of pollution control. In the field of molecular toxicology, his work has led to understand the molecular origin of drug interactions involving macrolideantibiotics such as TAO and of immunoallergic drug hepatitis due to tienilic acid.
He is the author or co-author of more than 400 scientific publications.[6]
^Mansuy, Daniel; Battioni, Jean Paul; Lavallee, David K.; Fischer, Jean; Weiss, Raymond (1988). "Nature of the complexes derived from the reaction of 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT) with iron porphyrins: Crystal and molecular structure of the vinylidene carbene complex Fe(TPP)(C:C(p-ClC6H4)2)". Inorganic Chemistry. 27 (6): 1052–1056. doi:10.1021/ic00279a023.
^Mansuy, Daniel; Lange, Marc; Chottard, J. C.; Bartoli, J. F.; Chevrier, Bernard; Weiss, Raymond (1978). "Dichlorocarbene Complexes of Iron(II)-Porphyrins–Crystal and Molecular Structure of Fe(TPP)(CCl2)(H2O)". Angewandte Chemie International Edition in English. 17 (10): 781–782. doi:10.1002/anie.197807811.
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