DNPEP

DNPEP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DYO
Identifiers
Aliases	DNPEP, ASPEP, DAP, aspartyl aminopeptidase
External IDs	OMIM: 611367; MGI: 1278328; HomoloGene: 6110; GeneCards: DNPEP; OMA:DNPEP - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,400,022 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	75,294,634 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; canal of the cervix; ; gastric mucosa; ; apex of heart; ; mucosa of transverse colon; ; right ovary; ; left uterine tube; ; upper lobe of left lung; ; ectocervix;
	Top expressed in
	intestinal villus; ; internal carotid artery; ; external carotid artery; ; Rostral migratory stream; ; epithelium of small intestine; ; aortic valve; ; ascending aorta; ; lobe of prostate; ; gastrula; ; endocardial cushion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; zinc ion binding; aminopeptidase activity; protein binding; hydrolase activity; metallopeptidase activity; metal ion binding; metalloaminopeptidase activity; identical protein binding;
Cellular component	blood microparticle; nucleus; cytosol; cytoplasm; extracellular region;
Biological process	proteolysis; peptide metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23549
	13437
	ENSG00000123992
	ENSMUSG00000026209
	Q9ULA0
	Q9Z2W0
NM_012100; NM_001319116; NM_001319117; NM_001319118; NM_001319119;
	NM_001319120; NM_001319121; NM_001319122
	NM_001110831; NM_016878
NP_001306045; NP_001306046; NP_001306047; NP_001306048; NP_001306049;
	NP_001306050; NP_001306051; NP_036232; NP_001306050.1; NP_001306051.1
	NP_001104301; NP_058574
	Wikidata
View/Edit Human	View/Edit Mouse

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.^[5]^[6]

Function

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in the general metabolism of intracellular proteins.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026209 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wilk S, Wilk E, Magnusson RP (Jun 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". The Journal of Biological Chemistry. 273 (26): 15961–70. doi:10.1074/jbc.273.26.15961. PMID 9632644.
^ ^a ^b "Entrez Gene: DNPEP aspartyl aminopeptidase".

External links

The MEROPS online database for peptidases and their inhibitors: M18.002
PDBe-KB provides an overview of all the structure information available in the PDB for Human Aspartyl aminopeptidase (DNPEP)