He has conducted seminal research on the neuropsychiatric disturbances (NPS) associated with degenerative brain disease including studies of patterns of occurrence and impact of NPS on dementia or transition from normal to Mild cognitive impairment (MCI) to dementia.[7] Lyketsos’ team is developing biomarkers to accelerate treatment development for Alzheimer's disease and other forms of brain injury.[8]
He was a Senior fellow at the school of medicine, Johns Hopkins University. He previously served as Chair of the Academy of Psychosomatic Medicine Taskforce on Subspecialization which spearheaded approval of the Psychiatric subspecialty of Consultation Liaison Psychiatry in 2004.[9][10]
As of 1 July 2021, Lyketsos’ scholarly work had an h-index of 129, with more than 58,000 citations.[11]
Margaret S. Chisolm and Constantine G. Lyketsos. “Systematic Psychiatric Evaluation: A Step-by-Step Guide to applying the perspectives of psychiatry. 2012.
Peter V. Rabins and Constantine G. Lyketsos. “Practical Dementia Care”. 1999.[17]
Editors with Constantine G. Lyketsos. “Designing and delivering dementia services”.[18]
Editors with Constantine G. Lyketsos. “Treating Dementia: Do we have a pill for it?”.[19]
Constantine G. Lyketsos with Editors. “Psychiatric Aspects of Neurologic Diseases: Practical Approaches to Patient Care”.[20]
^Rabins, Peter V. (1999). Practical dementia care. Lyketsos, Constantine G., Steele, Cynthia, 1947-. New York: Oxford University Press. ISBN0-19-510625-3. OCLC40331195.
^Designing and delivering dementia services. De Waal, Hugo (Hugo Eduard), 1956-. Chichester, West Sussex, UK: Wiley-Blackwell. 2013. ISBN978-1-118-37868-7. OCLC828193852.{{cite book}}: CS1 maint: others (link)
^Treating dementia: do we have a pill for it?. Ballenger, Jesse F. Baltimore: Johns Hopkins University Press. 2009. ISBN978-0-8018-9365-0. OCLC293339793.{{cite book}}: CS1 maint: others (link)
^Psychiatric aspects of neurologic diseases: practical approaches to patient care. Lyketsos, Constantine G. Oxford: Oxford University Press. 2008. ISBN978-1-4356-3357-5. OCLC213447266.{{cite book}}: CS1 maint: others (link)