Sterling-Brown was born in Brighouse, Calderdale, but split growing up between there and Hertfordshire.[1][2] She attended Lightcliffe Academy from 2008 to 2015.[3] Sterling-Brown wanted to pursue a career in law as a teenager, but was advised by her drama teacher to pursue acting. She turned down a place at law school despite her mother wanting her to take law.[4] She then obtained a BA in acting at the University of Central Lancashire (UCLan) from 2015 to 2018. When she started at UCLan, she began appearing in various stage productions, making her stage debut as the lead role in Hedda Gabler.[5] In 2018, after leaving university, she moved to Manchester and began volunteering at her local Samaritans branch since a man she knew killed himself. She continues to volunteer at least once a week alongside her acting, as well as singing in a band at her local church.[4]
Sterling-Brown auditioned for the role of Naomi Walters in the ITV1 soap opera Emmerdale, but lost out to Karene Peter. However, later that year, she was cast in the ITV1 soap opera Coronation Street as Dee Dee Bailey, the daughter of the established Bailey family.[6][7] The role marked Sterling-Brown's first major television role, after previously doing advertisements for Samaritans and various other mental health campaigns.[4] Six months into her tenure, she was nominated for the British Soap Award for Best Newcomer,[8] which she went on to win.[9] She has also been nominated within the Rising Star category at the 28th National Television Awards,[10] as well as Best Newcomer at the 2023 Inside Soap Awards.[11]