Hormones play a dominant role in the formation of cellulite. Estrogen is thought to be an important hormone in the development of cellulite, and it has been proposed that an imbalance of estrogen relative to progesterone may be associated with cellulite. However, there has been no reliable clinical evidence to support the claim that estrogen levels are linked to cellulite, and many women with elevated estrogen levels do not get cellulite.[8] Other hormones—including insulin, the catecholaminesadrenaline, cortisol and noradrenaline, thyroid hormones, and prolactin—are believed to participate in the development of cellulite.[1]
Genetic factors
There is a genetic element in individual susceptibility to cellulite.[1] Researchers have traced the genetic component of cellulite to particular polymorphisms in the angiotensin converting enzyme (ACE) and hypoxia-inducible factor 1A (HIF1a) genes.[9] Evidence for the heredity of cellulite is supported from studies showing that both the presence and degree of cellulite is similar between females within the same family.[6]
Predisposing factors
Several factors have been shown to affect the development of cellulite. Sex, ethnicity, biotype, distribution of subcutaneous fat, and predisposition to lymphatic and circulatory insufficiency have all been shown to contribute to cellulite.[1] It has been found to be considerably less common in women of East Asian descent, than in white women.[5]
Lifestyle
A high-stress lifestyle causes an increase in the level of catecholamines, which have also been associated with the development of cellulite.[1] Inactivity can cause vascular stasis, contributing to cellulite formation.[5] Excessive carbohydrate consumption may also be related to cellulite in some instances.[5]
Treatments
Cellulite can be resistant to a variety of treatments.[10] Aside from "topical" products (creams, ointments) and injectables (collagenase), treatments for cellulite include non-invasive therapy such as mechanical suction or mechanical massage. Energy-based devices include radio frequency with deep penetration of the skin, ultrasound,[11] cryotherapy chambers,[12] laser and pulsed-light devices.[13][14] Combinations of mechanical treatments and energy-based procedures are widely used.[13]Ionithermie, a form of electrotherapy using electrical muscle stimulation, has been described as ineffective.[15][16] More invasive 'subcision' techniques utilize a needle-sized microscalpel to cut through the causative fibrous bands of connective tissue. Subcision procedures (manual, vacuum-assisted, or laser-assisted) are performed in specialist clinics with patients given local anaesthetic.[14]
Epidemiology
In European populations, cellulite is thought to occur in 80–90% of post-adolescent females.[9][17] Its existence as a real disorder has been challenged,[18] and the prevailing medical opinion is that it is merely the "normal condition of many women".[19] It is rarely seen in males.[1]
History
The growing interest in cellulite has historically been linked to the growth of the cosmetic industry in the west, as well as globalization. The term was first used in the 1920s by spa and beauty services to promote their services, and began appearing in English-language publications in the late 1960s, with the earliest reference in Vogue magazine, "Like a swift migrating fish, the word cellulite has suddenly crossed the Atlantic."[20] According to Italian researcher Martina Grimaldi, cellulite has often been pathologized as a "disease" in Western European news media, and it has been shown that French magazines promoting this misinformation are often funded by pharmaceutical companies that manufacture anti-cellulite skincare products.[21] American journalist Susan Faludi notes that the Western beauty advertisements have attempted to portray cellulite as a symptom of women's social progress; that cellulite is caused by being a working, independent woman. Faludi writes that such messaging is motivated by a fear within the cosmetic industry that women's social progress might lead to declining profits in the beauty industry as a whole, noting that profits did decline in the 1970s and 1980s, the era of second-wave feminism.[22]
^ abRao, Jaggi; Gold, Michael H; Goldman, Mitchel P (2005). "A two-center, double-blinded, randomized trial testing the tolerability and efficacy of a novel therapeutic agent for cellulite reduction". Journal of Cosmetic Dermatology. 4 (2). Wiley: 96. doi:10.1111/j.1473-2165.2005.40208.x. ISSN1473-2130. PMID17166206. S2CID10123904. "heredity: empirically, it has been found that the degree and presence of cellulite, as with body habitus, is often similar between females within the same family; race: Caucasian women are more likely to develop cellulite than Asian or African American women;9
^ abEmanuele, E; Bertona, M; Geroldi, D (2010). "A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite". Journal of the European Academy of Dermatology and Venereology. 24 (8): 930–5. doi:10.1111/j.1468-3083.2009.03556.x. PMID20059631. S2CID26214159.
^Rossi, Anthony M.; Katz, Bruce E. (2014). "A Modern Approach to the Treatment of Cellulite". Dermatologic Clinics. 32 (1): 51–9. doi:10.1016/j.det.2013.09.005. PMID24267421.
^Juhász M, Korta D, Mesinkovska NA (2018). "A Review of the Use of Ultrasound for Skin Tightening, Body Contouring, and Cellulite Reduction in Dermatology". Dermatol Surg. 44 (7): 949–963. doi:10.1097/DSS.0000000000001551. PMID29846343. S2CID44101405.
^Nürnberger, F.; Müller, G. (1978). "So-Called Cellulite: An Invented Disease". The Journal of Dermatologic Surgery and Oncology. 4 (3): 221–9. doi:10.1111/j.1524-4725.1978.tb00416.x. PMID632386.
^Hackett, Paul M. W.; Hayre, Christopher M. (2 December 2020). Handbook of Ethnography in Healthcare Research. Routledge. p. 166. ISBN978-1-000-26398-5. In the text "The female body between science and guilt: The story of cellulite", Ghigi (2004) explains the role of French magazines in the construction of the concept of cellulite. It shows how two French magazines, "Votre Beaute" and "Marie Claire" have helped to show cellulite as a disease. In fact, these are two newspapers funded by pharmaceutical companies that manufacture anti-cellulite products.
Khan, Misbah H.; Victor, Frank; Rao, Babar; Sadick, Neil S. (2010). "Treatment of cellulite. Part I. Pathophysiology". Journal of the American Academy of Dermatology. 62 (3): 361–70, quiz 371–2. doi:10.1016/j.jaad.2009.10.042. PMID20159304.
Khan, Misbah H.; Victor, Frank; Rao, Babar; Sadick, Neil S. (2010). "Treatment of cellulite. Part II. Advances and controversies". Journal of the American Academy of Dermatology. 62 (3): 373–84, quiz 385–6. doi:10.1016/j.jaad.2009.10.041. PMID20159305.
