CITED1

CITED1
Identifiers
Aliases	CITED1, MSG1, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
External IDs	OMIM: 300149; MGI: 108023; HomoloGene: 3057; GeneCards: CITED1; OMA:CITED1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 72,301,638 bp[1] End 72,307,187 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X D|X 45.25 cM Start 101,290,987 bp[2] End 101,295,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis anterior pituitary Hypothalamus testicle prefrontal cortex anterior cingulate cortex Amygdala dorsolateral prefrontal cortex superior frontal gyrus Top expressed in yolk sac morula tail of embryo reticular formation atrium paraxial mesoderm lactiferous gland raphe nuclei endocardium endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity co-SMAD binding protein homodimerization activity DNA-binding transcription factor activity chromatin binding LBD domain binding protein C-terminus binding protein binding Cellular component cytoplasm cytosol nucleus nucleoplasm Biological process negative regulation of neuron apoptotic process response to transforming growth factor beta positive regulation of transforming growth factor beta receptor signaling pathway cell differentiation response to cytokine melanin biosynthetic process spongiotrophoblast layer development response to interleukin-1 regulation of transcription, DNA-templated SMAD protein signal transduction response to interleukin-4 response to interferon-gamma response to interleukin-6 placenta development regulation of transcription by RNA polymerase II response to interleukin-2 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis labyrinthine layer development response to interleukin-11 negative regulation of Wnt signaling pathway embryonic axis specification negative regulation of osteoblast differentiation transcription, DNA-templated response to estrogen vasculogenesis positive regulation of transcription, DNA-templated response to insulin multicellular organism development response to lipopolysaccharide branching involved in ureteric bud morphogenesis brain development positive regulation of gene expression response to parathyroid hormone nucleocytoplasmic transport pigmentation response to cAMP cell population proliferation metanephros development melanocyte differentiation negative regulation of transcription, DNA-templated response to interleukin-9 transforming growth factor beta receptor signaling pathway mesenchymal to epithelial transition apoptotic process positive regulation of transcription by RNA polymerase II regulation of apoptotic process transcription by RNA polymerase II positive regulation of mesenchymal stem cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4435 12705 Ensembl ENSG00000125931 ENSMUSG00000051159 UniProt Q99966 P97769 RefSeq (mRNA) NM_001144885 NM_001144886 NM_001144887 NM_004143 NM_001276466 NM_001276473 NM_001276474 NM_007709 RefSeq (protein) NP_001138357 NP_001138358 NP_001138359 NP_004134 NP_001263395 NP_001263402 NP_001263403 NP_031735 Location (UCSC) Chr X: 72.3 – 72.31 Mb Chr X: 101.29 – 101.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.[5][6][7]

Interactions

CITED1 has been shown to interact with HSPA8[8] and EP300.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000125931 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051159 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
6. Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics. 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
7. "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".
8. Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12). UNITED STATES: 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

External links

• Human CITED1 genome location and CITED1 gene details page in the UCSC Genome Browser.

Further reading

• Shioda T, Fenner MH, Isselbacher KJ (1998). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene. 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
• Li H, Ahmed NU, Fenner MH, et al. (1998). "Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells". Exp. Cell Res. 242 (2): 478–86. doi:10.1006/excr.1998.4123. PMID 9683535.
• Shioda T, Lechleider RJ, Dunwoodie SL, et al. (1998). "Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9785–90. Bibcode:1998PNAS...95.9785S. doi:10.1073/pnas.95.17.9785. PMC 21414. PMID 9707553.
• Vachtenheim J, Novotná H (2000). "Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas". Cell. Mol. Biol. (Noisy-le-grand). 45 (7): 1075–82. PMID 10644012.
• Yahata T, de Caestecker MP, Lechleider RJ, et al. (2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. PMID 10722728.
• Ahmed NU, Shioda T, Coser KR, et al. (2001). "Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo". Pigment Cell Res. 14 (2): 140–3. PMID 11310794.
• Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
• Yahata T, Shao W, Endoh H, et al. (2001). "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein". Genes Dev. 15 (19): 2598–612. doi:10.1101/gad.906301. PMC 312794. PMID 11581164.
• Bragança J, Swingler T, Marques FI, et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shi G, Boyle SC, Sparrow DB, et al. (2006). "The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner". J. Biol. Chem. 281 (37): 27426–35. doi:10.1074/jbc.M602631200. PMID 16864582.
• Lovvorn HN, Westrup J, Opperman S, et al. (2007). "CITED1 expression in Wilms' tumor and embryonic kidney". Neoplasia. 9 (7): 589–600. doi:10.1593/neo.07358. PMC 1941694. PMID 17710162.