Beta-amyrin 11-oxidase

Beta-amyrin 11-oxidase
Identifiers
EC no.	1.14.13.134
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-amyrin 11-oxidase (EC 1.14.13.134, CYP88D6) is an enzyme with systematic name beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating).[1] This enzyme catalyses the following chemical reaction

beta-amyrin + 2 O₂ + 2 NADPH + 2 H^+ ${\displaystyle \rightleftharpoons }$ 11-oxo-beta-amyrin + 3 H₂O + 2 NADP^+ (overall reaction)

(1a) beta-amyrin + O₂ + NADPH + H^+ ${\displaystyle \rightleftharpoons }$ 11alpha-hydroxy-beta-amyrin + H₂O + NADP^+

(1b) 11alpha-hydroxy-beta-amyrin + O₂ + NADPH + H^+ ${\displaystyle \rightleftharpoons }$ 11-oxo-beta-amyrin + 2 H₂O + NADP^+

Beta-amyrin 11-oxidase requires cytochrome P450.

References

1. Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T (September 2008). "Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin". Proceedings of the National Academy of Sciences of the United States of America. 105 (37): 14204–9. Bibcode:2008PNAS..10514204S. doi:10.1073/pnas.0803876105. PMC 2532699. PMID 18779566.

External links

• Beta-amyrin+11-oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)