Protein-coding gene in the species Homo sapiens
BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.[ 5] [ 6] [ 7]
This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[ 7]
Interactions
BCCIP has been shown to interact with BRCA2 ,[ 5] P21 ,[ 6] PTPRM )[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000107949 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030983 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Liu J, Yuan Y, Huan J, Shen Z (Apr 2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2" . Oncogene . 20 (3): 336– 45. doi :10.1038/sj.onc.1204098 PMID 11313963 . ^ a b Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H (Oct 2000). "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase" . J Biol Chem . 275 (40): 31145– 54. doi :10.1074/jbc.M003031200 PMID 10878006 . ^ a b "Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein" .^ Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM (2008). "BCCIP associates with the receptor protein tyrosine phosphatase PTPmu" . J Cell Biochem . 105 (4): 1059– 72. doi :10.1002/jcb.21907 . PMC 2758318 PMID 18773424 .
External links
Further reading
Coleman RA, Rao P, Fogelsong RJ, Bardes ES (1992). "2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes". Biochim. Biophys. Acta . 1125 (2): 203– 9. doi :10.1016/0005-2760(92)90046-X . PMID 1571364 . Machackova E, Damborsky J, Valik D, Foretova L (2002). "Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic" . Hum. Mutat . 18 (6): 545. doi :10.1002/humu.1232 PMID 11748848 . S2CID 8549550 . Armakolas A, Ladopoulou A, Konstantopoulou I, et al. (2002). "BRCA2 gene mutations in Greek patients with familial breast cancer" . Hum. Mutat . 19 (1): 81– 2. doi :10.1002/humu.9003 PMID 11754111 . S2CID 25598124 . Robson M, Scheuer L, Nafa K, et al. (2002). "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer" . J. Med. Genet . 39 (2): 126– 8. doi :10.1136/jmg.39.2.126 . PMC 1735025 PMID 11836363 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". Gene . 302 (1– 2): 139– 46. doi :10.1016/S0378-1119(02)01098-3 . PMID 12527204 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Meng X, Liu J, Shen Z (2004). "Inhibition of G1 to S cell cycle progression by BCCIP beta" . Cell Cycle . 3 (3): 343– 8. doi :10.4161/cc.3.3.672 PMID 14726710 . Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375– 81. Bibcode :2004Natur.429..375D . doi :10.1038/nature02462 PMID 15164054 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324– 32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Meng X, Lu H, Shen Z (2007). "BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1" . Cell Cycle . 3 (11): 1457– 62. doi :10.4161/cc.3.11.1213 PMID 15539944 . Lu H, Guo X, Meng X, et al. (2005). "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair" . Mol. Cell. Biol . 25 (5): 1949– 57. doi :10.1128/MCB.25.5.1949-1957.2005 . PMC 549367 PMID 15713648 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957– 68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Meng X, Yue J, Liu Z, Shen Z (2007). "Abrogation of the transactivation activity of p53 by BCCIP down-regulation" . J. Biol. Chem . 282 (3): 1570– 6. doi :10.1074/jbc.M607520200 PMC 2679999 PMID 17135243 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
