Autologous stem-cell transplantation

Autologous stem-cell transplantation (also called autogenous, autogenic, or autogenic stem-cell transplantation and abbreviated auto-SCT) is the autologous transplantation of stem cells[1][2][3][4]—that is, transplantation in which stem cells (undifferentiated cells from which other cell types develop) are removed from a person, stored, and later given back to that same person.[4][5][6]

Although it is most frequently performed with hematopoietic stem cells (precursors of blood-forming cells) in hematopoietic stem cell transplantation, cardiac cells have also been used successfully to repair damage caused by heart attacks.[7][3][8]

Autologous stem-cell transplantation is distinguished from allogenic stem cell transplantation where the donor and the recipient of the stem cells are different people.[2]

It can be also used as an Assisted reproductive technology to improve the reproductive outcomes. In a first step the bone marrow derived stem cells are mobilized. After that they will be isolated from the peripheral blood by apheresis. The treated stem cells will then be infused into the ovarian artery through catheterism.

See also

• Autologous hematopoietic stem-cell transplantation
• Stem-cell therapy

References

1. "What Are Stem Cells?". Retrieved 2017-02-12.
2. Al-Daccak, R.; Charron, D. (2015-07-23). "Allogenic benefit in stem cell therapy: cardiac repair and regeneration". Tissue Antigens. 86 (3): 155–162. doi:10.1111/tan.12614. ISSN 0001-2815. PMID 26206374.
3. Nakashima, Yasuhiro; Nakano, Atsushi (2013-04-10), "Cardiac Regeneration Using Isl1-positive Cardiac Progenitor Cells", Cardiac Regeneration using Stem Cells, CRC Press, pp. 185–209, doi:10.1201/b14990-12 (inactive 2024-11-11), retrieved 2023-09-23
4. Mahla RS (2016). "Stem cells application in regenerative medicine and disease threpeutics". International Journal of Cell Biology. 2016 (7): 19. doi:10.1155/2016/6940283. PMC 4969512. PMID 27516776.
5. "Autologous (Self) Transplants". The Leukaemia Foundation. Archived from the original on 17 March 2018. Retrieved 27 September 2017.
6. Cells Editorial Office (2020-01-19). "Acknowledgement to Reviewers of Cells in 2019". Cells. 9 (1): 150–151. doi:10.3390/cells9010251. ISSN 2073-4409. PMC 3980745.
7. Stamm, Christof; Westphal, Bernd; Kleine, Hans-Dieter; Petzsch, Michael; Kittner, Christian; Klinge, Heiko; Schümichen, Carl; Nienaber, Christoph A; Freund, Mathias (2003-01-04). "Autologous bone-marrow stem-cell transplantation for myocardial regeneration". The Lancet. 361 (9351): 45–46. doi:10.1016/S0140-6736(03)12110-1. PMID 12517467. S2CID 23858666.
8. "Human/Sheep Hematopoietic Chimeras", Hematopoietic Stem Cell Transplantation, CRC Press, pp. 166–183, 2000-07-25, doi:10.1201/b14000-13, ISBN 978-0-429-16445-3, retrieved 2023-09-23

9. Herraiz et al., (2018). Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders. Fertil Steril, 110(3), 496-505.

•  This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.

External links

• Autologous stem-cell transplantation entry in the public domain NCI Dictionary of Cancer Terms
• ScienceDaily Report Archived 2017-01-16 at the Wayback Machine University of Louisville. "Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests." ScienceDaily, 6 Nov. 2012. Web. 6 Nov. 2012.