Autoimmune/inflammatory syndrome induced by adjuvants
Hypothesised autoimmune disorder
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), or Shoenfeld's syndrome, is a hypothesised autoimmune disorder proposed by Israeli immunologist Yehuda Shoenfeld in 2011.[1] According to Shoenfeld, the syndrome is triggered by exposure to adjuvants and includes four conditions: "post-vaccination symptoms", macrophagic myofasciitis, Gulf war syndrome, sick building syndrome, and siliconosis.[2][3] Apart from the theoretical concept of ASIA, there no evidence for any causal relationship between adjuvant and autoimmune condition.[4] A study of 18,000 people showed that there is no merit to the theory of autoimmune/inflammatory syndrome induced by adjuvants.[5] Shoenfeld alleges that the syndrome is caused by adjuvants such as silicone, tetramethylpentadecane, pristane, and aluminum.[6] However, causality is difficult to prove because ASIA only occurs in a small fraction of patients exposed to these adjuvants.[7] Additionally, proponents of this theory allege that the disorder can manifest anywhere from 2 days to 23 years after exposure.[3] Shoenfeld has also named Sjögren's syndrome as potentially being another facet of ASIA.[8]
^Hawkes D.; et al. (May 2015). "Revisiting adverse reactions to vaccines: A critical appraisal of Autoimmune Syndrome Induced by Adjuvants (ASIA)". J. Autoimmun. 59: 77–84. doi:10.1016/j.jaut.2015.02.005. PMID25794485.
