Lopes joined Grêmio in 2007, taking over the under-20s. On 7 September 2010, he was named Renato Portaluppi's assistant at the main squad,[2] but returned to his previous role the following 4 August.[1]
Dismissed by Grêmio in 2012, Lopes was manager of Cerâmica's under-20s for a short period[3] before joining Dunga's staff back at Internacional in December of that year.[4] On 22 July 2014, after Dunga was named manager of the Brazil national team, Lopes was again appointed as his assistant.[5] He left in October of the following year, after Dunga was fired, and was named assistant at Palmeiras on 12 December 2017.[6]
On 2 December 2019, Lopes was appointed interim manager of Palmeiras, replacing sacked Mano Menezes.[7] His first match in charge occurred three days later, a 5–1 home routing of Goiás.[8] He worked in another match before returning to his previous role.
On 15 October 2020, Lopes was again named interim after the dismissal of Vanderlei Luxemburgo.[9]