As a freshman at Syracuse in 2018, Cisco started 11 of 13 games.[5] He recorded 60 tackles and seven interceptions, which was tied for most in the nation.[6] He was the ACC Defensive Rookie of the Year and was a freshman All-American.[7] Cisco started nine games his sophomore season, missing three due to injury, and had 65 tackles, five interceptions and a touchdown.[8]
Cisco was selected by the Jacksonville Jaguars in the third round (65th overall) of the 2021 NFL draft.[11] He signed his four-year rookie contract with the Jaguars on June 10, 2021.[12] Cisco appeared in 17 games, of which he started the last three, as a rookie. He totaled 26 total tackles, two passes defended, and two forced fumbles.[13]
In Week 4 of the 2022 season, against the Philadelphia Eagles, Cisco recorded a 59-yard interception return for a touchdown in the 29–21 loss.[14] He appeared in 15 games, of which he started all of them. He finished with one sack, 73 total tackles, three interceptions, and ten passes defended.[15]