Paknadel's first professionally published a comic book in 2015 with Arcadia through Archaia Entertainment, which was inspired by the documentary All Watched Over by Machines of Loving Grace.[2] In 2017, he co-wrote Assassin's Creed: Uprising alongside Dan Watters[3] and then, in 2018, he published Friendo through Vault Comics, which Paste Magazine listed as one of the 15 Best Sci-Fi & Fantasy Comics of 2018.[4] Paknadel, who is part of White Noise, a "studio/comics collective" that also includes Ram V, Dan Watters, and Ryan O'Sullivan,[5][6] was then announced to have new comics, including Earthcrosser[7] and, in 2020, Giga, a science-fiction murder mystery with mechas.[8][9] Also in 2020, Paknadel published Redfork, a horror comic about "the opioid crisis, economic despair, and cosmic as well as capitalistic horror, all seeping into an Appalachian town" through TKO Studios.[10] In 2022, his first Image Comics book was announced, All Against All, which was billed as "Aliens meets Tarzan."[11]
Paknadel began his Marvel career with the 2020 one-shots Lords of Empyre: Celestial Messiah and Lords of Empyre: Swordsman.[12] He followed that up in 2021 by co-writing Immortal Hulk: Time of Monsters with Al Ewing[13][14][15] and then writing the tie-ins Death of Doctor Strange: Avengers[16] and Darkhold: Spider-Man.[17] In 2023, he was announced as the writer, alongside artist Jan Bazaldua, for Red Goblin,[18] about Normie Osborn, the Green Goblin's grandson, and his symbiote "Rascal." "He has in his possession a weapon that could well unleash the sadism and depravity his family name makes him heir to, but he's choosing to go the other way. In brief, I want people to root for this poor kid and his weird murderous pal because although the path they're walking is crooked and perilous, the end goal is truly noble."[19] At the same time, he took over writing Carnage and co-wrote, alongside writer Cody Ziglar, the crossover Carnage Reigns.[20][21]
In 2024, he was announced as the main writer for the X-Men: From the AshesInfinity Comic.[27] "In some respects, my job here in these first arcs is to bridge the gap between Krakoa and the new status quo." He was then announced as the writer for the upcoming X-Men mini-series Sentinels.[28] Unlike previous Sentinels, these new Sentinels are human cyborgs who have been augmented with Sentinel nanotechnology and set to hunt evil mutants. "Being a Reaver is a hideous calling; being one of our new Sentinels is a job. Many would argue — not without merit — that the latter is worse, and that ethical quagmire is kind of where this series lives. At what point does blindly following orders make you complicit?"[29]
He lives in London, England, and graduated with a PhD in English literature from Lancaster University.[1] Before writing comics, he worked for a digital marketing company.[33] He is the son of mystery writer Barbara Nadel.[34]