ADAM9

ADAM9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M1V
Identifiers
Aliases	ADAM9, CORD9, MCMP, MDC9, Mltng, ADAM metallopeptidase domain 9
External IDs	OMIM: 602713; MGI: 105376; HomoloGene: 20824; GeneCards: ADAM9; OMA:ADAM9 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.22 Start 38,996,754 bp[1] End 39,105,445 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 13.7 cM Start 25,439,627 bp[2] End 25,506,943 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium islet of Langerhans gallbladder smooth muscle tissue right lung Descending thoracic aorta Achilles tendon ascending aorta upper lobe of left lung rectum Top expressed in endothelial cell of lymphatic vessel stroma of bone marrow seminal vesicula retinal pigment epithelium epithelium of lens left lung lobe Paneth cell right lung parotid gland gastric mucosa More reference expression data BioGPS n/a
Gene ontology Molecular function collagen binding SH3 domain binding metal ion binding integrin binding peptidase activity protein binding metalloendopeptidase activity laminin binding hydrolase activity metallopeptidase activity protein kinase C binding Cellular component integral component of membrane membrane focal adhesion intrinsic component of external side of plasma membrane plasma membrane extracellular region extracellular exosome cell surface basolateral plasma membrane extracellular space Biological process positive regulation of membrane protein ectodomain proteolysis response to glucocorticoid positive regulation of macrophage fusion cell-cell adhesion mediated by integrin keratinocyte differentiation proteolysis monocyte activation response to calcium ion response to tumor necrosis factor positive regulation of keratinocyte migration cell adhesion response to manganese ion membrane protein ectodomain proteolysis positive regulation of protein secretion integrin-mediated signaling pathway positive regulation of cell adhesion mediated by integrin cell-matrix adhesion cellular response to lipopolysaccharide transforming growth factor beta receptor signaling pathway response to hydrogen peroxide cell migration cell adhesion mediated by integrin response to laminar fluid shear stress response to antineoplastic agent Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8754 11502 Ensembl ENSG00000168615 ENSG00000282230 ENSMUSG00000031555 UniProt Q13443 Q61072 RefSeq (mRNA) NM_001005845 NM_003816 NM_001270996 NM_007404 RefSeq (protein) NP_003807 NP_001257925 NP_031430 Location (UCSC) Chr 8: 39 – 39.11 Mb Chr 8: 25.44 – 25.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.[5][6]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.[6]

Interactions

ADAM9 has been shown to interact with:

• MAD2L2,[7]
• SH3GL2,[8] and
• SNX9[8]

References

1. ENSG00000282230 GRCh38: Ensembl release 89: ENSG00000168615, ENSG00000282230 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031555 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Weskamp G, Kratzschmar J, Reid MS, Blobel CP (Jul 1996). "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains". J Cell Biol. 132 (4): 717–26. doi:10.1083/jcb.132.4.717. PMC 2199860. PMID 8647900.
6. "Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)".
7. Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 (Pt 3): 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
8. Howard L, Nelson KK, Maciewicz RA, Blobel CP (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.

Further reading

• Mazzocca A, Coppari R, De Franco R, Cho JY, Libermann TA, Pinzani M, Toker A (June 2005). "A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions". Cancer Res. 65 (11): 4728–38. doi:10.1158/0008-5472.CAN-04-4449. PMID 15930291.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• McKie N, Dallas DJ, Edwards T, et al. (1996). "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells". Biochem. J. 318 (2): 459–62. doi:10.1042/bj3180459. PMC 1217643. PMID 8809033.
• McKie N, Edwards T, Dallas DJ, et al. (1997). "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes". Biochem. Biophys. Res. Commun. 230 (2): 335–9. doi:10.1006/bbrc.1996.5957. PMID 9016778.
• Izumi Y, Hirata M, Hasuwa H, et al. (1999). "A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor". EMBO J. 17 (24): 7260–72. doi:10.1093/emboj/17.24.7260. PMC 1171072. PMID 9857183.
• Roghani M, Becherer JD, Moss ML, et al. (1999). "Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity". J. Biol. Chem. 274 (6): 3531–40. doi:10.1074/jbc.274.6.3531. PMID 9920899.
• Nelson KK, Schlöndorff J, Blobel CP (2000). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 (3): 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
• Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
• Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.
• Namba K, Nishio M, Mori K, et al. (2002). "Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes". Cell. Immunol. 213 (2): 104–13. doi:10.1006/cimm.2001.1873. PMID 11831872.
• Eto K, Huet C, Tarui T, et al. (2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions". J. Biol. Chem. 277 (20): 17804–10. doi:10.1074/jbc.M200086200. PMID 11882657.
• Lim JM, Lee JH, Wee WR, Joo CK (2002). "Downregulated expression of ADAM9 in anterior polar cataracts". Journal of Cataract and Refractive Surgery. 28 (4): 697–702. doi:10.1016/S0886-3350(01)01236-6. PMID 11955914. S2CID 21982654.
• Hotoda N, Koike H, Sasagawa N, Ishiura S (2002). "A secreted form of human ADAM9 has an alpha-secretase activity for APP". Biochem. Biophys. Res. Commun. 293 (2): 800–5. doi:10.1016/S0006-291X(02)00302-9. PMID 12054541.
• Amour A, Knight CG, English WR, et al. (2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs". FEBS Lett. 524 (1–3): 154–8. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759. S2CID 37423323.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mohan S, Thompson GR, Amaar YG, et al. (2003). "ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts". Biochemistry. 41 (51): 15394–403. doi:10.1021/bi026458q. PMID 12484779.
• Asai M, Hattori C, Szabó B, et al. (2003). "Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase". Biochem. Biophys. Res. Commun. 301 (1): 231–5. doi:10.1016/S0006-291X(02)02999-6. PMID 12535668.
• O'Shea C, McKie N, Buggy Y, et al. (2003). "Expression of ADAM-9 mRNA and protein in human breast cancer". Int. J. Cancer. 105 (6): 754–61. doi:10.1002/ijc.11161. PMID 12767059. S2CID 19284959.
• Grützmann R, Lüttges J, Sipos B, et al. (2004). "ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma". Br. J. Cancer. 90 (5): 1053–8. doi:10.1038/sj.bjc.6601645. PMC 2409625. PMID 14997207.

External links

• ADAM9 on the Atlas of Genetics and Oncology
• Human ADAM9 genome location and ADAM9 gene details page in the UCSC Genome Browser.