ABCF1

ABCF1
Identifiers
Aliases	ABCF1, ABC27, ABC50, ATP binding cassette subfamily F member 1
External IDs	OMIM: 603429; MGI: 1351658; HomoloGene: 849; GeneCards: ABCF1; OMA:ABCF1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,597,179 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,280,653 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gastrocnemius muscle; ; skeletal muscle tissue; ; islet of Langerhans; ; muscle of thigh; ; placenta; ; ventricular zone; ; mucosa of transverse colon; ; stromal cell of endometrium; ; granulocyte;
	Top expressed in
	neural layer of retina; ; tail of embryo; ; Rostral migratory stream; ; genital tubercle; ; yolk sac; ; condyle; ; primitive streak; ; lacrimal gland; ; fetal liver hematopoietic progenitor cell; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ribosome binding; translation activator activity; translation factor activity, RNA binding; ATPase activity; protein binding; ATP binding; RNA binding;
Cellular component	cytoplasm; ribosome; nuclear envelope; membrane; nucleoplasm; nucleus; polysomal ribosome; cytosol;
Biological process	protein biosynthesis; ribosome biogenesis; positive regulation of translation; transmembrane transport; translational initiation; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	23
	224742
ENSG00000206490; ENSG00000225989; ENSG00000236149; ENSG00000232169; ENSG00000204574;
	ENSG00000236342; ENSG00000231129
	ENSMUSG00000038762
	Q8NE71
	Q6P542
	NM_001090; NM_001025091
	NM_013854
	NP_001020262; NP_001081
	NP_038882
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene.^[5]^[6]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains, characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancing protein synthesis and inflammation.^[6]