The 2021–22 season is MŠK Žilina's 114th season in existence and the club's 25th consecutive season in the top flight of Slovak football. In addition to the domestic league, Žilina participated in this season's edition of the Slovak Cup and the UEFA Europa Conference League.
Current squad
As of 4 August 2021[1]
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
As of 4 August 2021
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^Apollon Limassol will play their home match at AEK Arena, Larnaca, instead of their regular stadium Tsirion Stadium, Limassol, as another match is taking place at the same day.
^Tobol played their third qualifying round home match at Astana Arena, Nur-Sultan, instead of their regular stadium Kostanay Central Stadium, Kostanay, which did not meet UEFA requirements.