The 2021–22 season was ŠK Slovan Bratislava's 16th consecutive in the top flight of Slovak football.
Slovan successfully retained their league title, winning a record-breaking fourth title in a row and 12th overall since the competition was established in 1993. However, they were not successful in defending their Slovak Cup title, after losing in the final.
As league champion from the previous season, Slovan qualified for the UEFA Champions League. They were eliminated in the second qualifying round. Subsequently, Slovan competed in this season's edition of the UEFA Europa League, but were eliminated in the play-off round. Afterwards, Slovan were transferred to the group stage of the newly created UEFA Europa Conference League, where the club finished third and did not advance to the next stage of the competition.
The season covers the period from 1 June 2021 to 31 May 2022.
As part of the pre-season preparation, the club announced it would complete two training camps. One fitness training camp in Šamorín and then a training camp in Bad Tatzmannsdorf, Austria, where Slovan did participate in three pre-season fixtures. The final pre-season match was played in Bratislava.[25]
As part of the first block of the mid-season preparation, focused mainly on fitness, Slovan were to play one friendly match, but it was cancelled due to COVID-19 related issues. Subsequently, Slovan moved to Dubai, where they played three friendly matches. After returning home, the team played one more match.[26]
Note: The match was suspended after 15 minutes of play due to the riots of the spectators, who entered the pitch. Subsequently, the match was abandoned by the referee. On 20 October, Slovan were awarded a technical 3–0 victory by the Presidium of the Union of League Clubs, which is the governing organization for the Slovak top level football competition.[29]