The 2021–22 season was the 118th season in the existence of K.V. Mechelen and the club's third consecutive season in the top flight of Belgian football. In addition to the domestic league, Mechelen participated in this season's edition of the Belgian Cup.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: The result was awarded as 5–0 forfeit win due to Mechelen opting to not send their team after multiple COVID-19 cases. Their initial request to postpone the match was declined.
Source: Jupiler Pro League(in Dutch), Soccerway Rules for classification: 1) Points; 2) Points without (possible) half points added due to rounding; 3) Regular season finishing position.[12] Notes:
^Gent qualified for the Europa League play-off round as the 2021–22 Belgian Cup winners.