The 2020–21 Reading F.C. Women season was the club's 14th season and their sixth in the FA Women's Super League, the highest level of the football pyramid. Reading finished the season in 7th place, were knocked out of the FA Cup in the fourth round and finished second in their League Cup group.
On 4 September, Reading announced the signing of Jeon Ga-eul.[8]
On 8 January, midfielder Sophie Quirk moved to London Bees on loan for the remainder of the season.[9]
On 6 February, Reading announced the signing of Silvana Flores.[10] On 16 February, Grace Moloney extended her contract with Reading until the summer of 2023.[11]
On 19 February, Reading confirmed that Jess Fishlock's loan from OL Reign would end on 4 April,[12] with Brooke Chaplen extending her contract with the club until the summer of 2022 on 22 February.[13]
On 26 March, Rachel Rowe extended her contract with Reading until June 2024.[14]
On 26 April, Fara Williams announced that she would be retiring at the end of the season.[15]
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.