Akuaporin 3

AQP3
Pengidentifikasi
Alias	AQP3, AQP-3, GIL, aquaporin 3 (Gill blood group)
ID eksternal	OMIM: 600170 MGI: 1333777 HomoloGene: 21025 GeneCards: AQP3
Ontologi gen Fungsi molekuler • aktivitas saluran air • glycerol channel activity • aktivitas transporter • aktivitas saluran • urea transmembrane transporter activity Komponen seluler • sitoplasma • komponen integral membran • membran • cell-cell junction • Membran sel • membran plasma basolateral • Inti sel Proses biologis • positive regulation of immune system process • Ekskresi • respons terhadap vitamin D • respons terhadap asam retinoat • transpor air • urea transport • odontogenesis • response to calcium ion • renal water homeostasis • regulation of keratinocyte differentiation • renal water absorption • glycerol transport • cellular response to oxygen-glucose deprivation • respons seluler terhadap hipoksia • transpor transmembran • urea transmembrane transport Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	360	11828
Ensembl	ENSG00000165272	ENSMUSG00000028435
UniProt	Q92482	Q8R2N1
RefSeq (mRNA)	NM_004925 NM_001318144	NM_016689
RefSeq (protein)	NP_001305073 NP_004916	NP_057898
Lokasi (UCSC)	n/a	n/a
Pencarian PubMed	[1]	[2]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Akuaporin 3 ditemukan pada membran sel basolateral sel utama tubulus koligentes dan menyediakan jalur bagi air untuk keluar dari sel tersebut.[3] Di dalam ginjal, AQP3 diregulasi oleh vasopresin (ADH).[4] Protein ini juga merupakan determinan untuk sistem golongan darah GIL.[5]

Asam suberanilohidroksamat (SAHA) (inhibitor HDAC) meningkatkan ekspresi akuaporin-3 pada sel kulit normal (keratinosit).[6]

Signifikansi klinis

Konsentrasi AQP3 sering kali lebih rendah pada psoriasis dibandingkan dengan kulit sehat.[6]

AQP3 lebih diekspresikan pada eksem atopik.[7]

Lihat pula

• Akuaporin

Referensi

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461. 
4. Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (edisi ke-4): 346 – via Elsevier. 
5. Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. doi:10.1074/jbc.M208999200. PMID 12239222. 
6. Cancer therapy shows promise for psoriasis treatment
7. Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema". Allergy. 61 (9): 1132–7. doi:10.1111/j.1398-9995.2006.01151.x. PMID 16918518. 

Bacaan lanjutan

• Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte". Mol. Biochem. Parasitol. 167 (1): 48–53. doi:10.1016/j.molbiopara.2009.04.006. PMID 19393693. 
• Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations". Transfusion. 48 (6): 1164–8. doi:10.1111/j.1537-2995.2008.01683.x. PMID 18435676. 
• Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture". J. Soc. Gynecol. Investig. 13 (3): 181–5. doi:10.1016/j.jsgi.2006.02.002. PMID 16638588. 
• Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells". Respiratory physiology & neurobiology. 161 (2): 111–8. doi:10.1016/j.resp.2007.12.007. PMID 18280225. 
• Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine". Biochem. Biophys. Res. Commun. 373 (4): 613–7. doi:10.1016/j.bbrc.2008.06.086. PMID 18601899. 
• Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes". Biochem. Biophys. Res. Commun. 387 (3): 564–8. doi:10.1016/j.bbrc.2009.07.077. PMID 19619514. 
• Bellemère G, Von Stetten O, Oddos T (2008). "Retinoic acid increases aquaporin 3 expression in normal human skin". J. Invest. Dermatol. 128 (3): 542–8. doi:10.1038/sj.jid.5701047. PMID 17943189. 
• Cohly HH, Isokpehi R, Rajnarayanan RV (2008). "Compartmentalization of aquaporins in the human intestine". Int J Environ Res Public Health. 5 (2): 115–9. doi:10.3390/ijerph5020115. PMC 2694936 . PMID 18678926. 
• Lee TC, Ho IC, Lu WJ, Huang JD (2006). "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line". J. Biol. Chem. 281 (27): 18401–7. doi:10.1074/jbc.M601266200. PMID 16672223. 
• Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing". J. Mol. Med. 86 (2): 221–31. doi:10.1007/s00109-007-0272-4. PMID 17968524. 
• Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009). "The expression of differentiation markers in aquaporin-3 deficient epidermis". Arch. Dermatol. Res. 301 (3): 245–52. doi:10.1007/s00403-009-0927-9. PMC 3582396 . PMID 19184071. 
• Wang J, Tanji N, Kikugawa T, et al. (2007). "Expression of aquaporin 3 in the human prostate". Int. J. Urol. 14 (12): 1088–92; discussion 1092. doi:10.1111/j.1442-2042.2007.01901.x. PMID 18036046. 
• Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin". J. Cell. Biochem. 102 (4): 1051–8. doi:10.1002/jcb.21350. PMID 17471492. 
• Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation". J. Cell. Physiol. 217 (2): 338–49. doi:10.1002/jcp.21506. PMID 18543247. 
• Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc". J. Mol. Histol. 39 (3): 303–9. doi:10.1007/s10735-008-9166-1. PMID 18247144. 
• Avril-Delplanque A, Casal I, Castillon N, et al. (2005). "Aquaporin-3 expression in human fetal airway epithelial progenitor cells". Stem Cells. 23 (7): 992–1001. doi:10.1634/stemcells.2004-0197. PMID 16043462. 
• Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line". J. Membr. Biol. 208 (1): 55–64. doi:10.1007/s00232-005-0819-7. PMID 16596446. 
• Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues". Hum. Pathol. 38 (1): 171–8. doi:10.1016/j.humpath.2006.07.015. PMID 17056099. 

Pranala luar

• Sistem golongan darah GIL pada Basis Data Mutasi Gen Antigen Golongan Darah BGMUT di NCBI, NIH
• Lokasi genom AQP3 manusia dan halaman rincian gen AQP3 dalam UCSC Genome Browser.