zh IL4R

現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要

Interleukin-4 receptor alpha chain, N-terminal
Interleukin-4 receptor alpha chain, N-terminal
	interleukin-4 / receptor alpha chain complex
鑑定
標誌	IL4Ra_N
Pfam	PF09238（旧版）
InterPro（英语：InterPro）	IPR015319
SCOP（英语：Structural Classification of Proteins）	1iar / SUPFAM
Pfam
現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要

白細胞介素6受體
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1IAR、1IRS、3BPL、3BPN、3BPO、5E4E
識別號
别名	IL4R；, CD124, IL-4RA, IL4RA, Interleukin-4 receptor, interleukin 4 receptor
外部ID	OMIM：147781 MGI：105367 HomoloGene：7784 GeneCards：IL4R
基因位置（人类）
染色体	16號染色體
终止	27,364,778 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	125,178,646 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 血浆蛋白结合; • cytokine receptor activity; • interleukin-4 receptor activity;
細胞組分	• integral component of membrane; • 膜; • receptor complex; • integral component of plasma membrane; • 細胞外區域; • 細胞外空間; • 细胞膜;
生物學過程	• immune system process; • positive regulation of immunoglobulin production; • positive regulation of macrophage activation; • positive regulation of mast cell degranulation; • response to estrogen; • production of molecular mediator involved in inflammatory response; • positive regulation of myoblast fusion; • negative regulation of T-helper 1 cell differentiation; • regulation of cell population proliferation; • immunoglobulin mediated immune response; • 免疫反应; • positive regulation of T-helper 2 cell differentiation; • 排卵; • 訊息傳遞; • defense response to protozoan; • interleukin-4-mediated signaling pathway; • response to odorant; • cytokine-mediated signaling pathway; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	3566
	16190
	ENSG00000077238
	ENSMUSG00000030748
	P24394
	P16382
	NM_000418; NM_001008699; NM_001257406; NM_001257407; NM_001257997
	NM_001008700; NM_001363983
	NP_000409; NP_001244335; NP_001244336; NP_001244926
	NP_001008700; NP_001350912
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白介素-4受体α亚基（Interleukin-4 receptor subunit alpha，缩写IL4R-α或IL4R）也称为分化簇124（CD124，cluster of differentiation 124）是一种细胞表面蛋白质，由人类基因 IL4R 编码^[5]，与γ链（CD132）共同组成I型白介素-4受体（IL4R type I），或与白介素-13受体α1（CD213a1）组成II型白介素-4受体（IL4R type II），除了结合能白介素-4还能结合白介素-13（IL13）^[6]。

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000077238 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000030748 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: IL4R interleukin 4 receptor.
^ McCormick SM, Heller NM. Commentary: IL-4 and IL-13 receptors and signaling. Cytokine. September 2015, 75 (1): 38–50. PMC 4546937 . PMID 26187331. doi:10.1016/j.cyto.2015.05.023.

外部链接

醫學主題詞表（MeSH）：CD124+Antigen
PDBe-KB provides an overview of all the structure information available in the PDB for Human Interleukin-4 receptor subunit alpha

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000077238 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000030748 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Entrez Gene: IL4R interleukin 4 receptor.

[6] McCormick SM, Heller NM. Commentary: IL-4 and IL-13 receptors and signaling. Cytokine. September 2015, 75 (1): 38–50. PMC 4546937 . PMID 26187331. doi:10.1016/j.cyto.2015.05.023.

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