IL2RA

IL2RA
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1Z92、​2B5I、​2ERJ、​3IU3、​3NFP
識別號
别名	IL2RA；, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
外部ID	OMIM：147730 MGI：96549 HomoloGene：360 GeneCards：IL2RA
相關疾病
類風濕性關節炎、​1型糖尿病、​多发性硬化症、​克隆氏症、​圓禿、​type 1 diabetes mellitus 10、​CD25 deficiency[1]
基因位置（人类） 染色体 10號染色體[2] 基因座 10p15.1 起始 6,010,689 bp[2] 终止 6,062,370 bp[2]
基因位置（小鼠） 染色体 小鼠2号染色体[3] 基因座 2 A1|2 8.91 cM 起始 11,647,618 bp[3] 终止 11,698,004 bp[3]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • interleukin-2 receptor activity • interleukin-2 binding • 血浆蛋白结合 細胞組分 • integral component of membrane • 膜 • 细胞膜 • cell surface • external side of plasma membrane • 胞內 • interleukin-2 receptor complex 生物學過程 • Notch信号通路 • positive regulation of T cell differentiation • regulation of T cell tolerance induction • inflammatory response to antigenic stimulus • negative regulation of defense response to virus • immune system process • activation-induced cell death of T cells • negative regulation of lymphocyte proliferation • MAPK cascade • T cell homeostasis • regulation of T cell homeostatic proliferation • cell surface receptor signaling pathway • negative regulation of T cell proliferation • negative regulation of immune response • 免疫反应 • positive regulation of T cell proliferation • 細胞增殖 • inflammatory response • negative regulation of inflammatory response • positive regulation of activated T cell proliferation • 细胞凋亡 • regulation of regulatory T cell differentiation • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3559	16184
Ensembl	ENSG00000134460	ENSMUSG00000026770
UniProt	P01589	P01590
mRNA​序列	NM_000417 ​NM_001308242 ​NM_001308243	NM_008367
蛋白序列	NP_000408 ​NP_001295171 ​NP_001295172	NP_032393
基因位置​（UCSC）	Chr 10: 6.01 – 6.06 Mb	Chr 2: 11.65 – 11.7 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

白介素-2受体α亚基（Interleukin-2 receptor subunit alpha，缩写IL2RA）也称为Tac抗原（Tac antigen）、P55、分化簇25（CD25，cluster of differentiation 25）是一种细胞表面蛋白质，由人类基因 IL2RA 编码[6]，与β亚基（CD122）、γ亚基（CD132）共同组成白介素-2受体[7]。

参考资料

1. 與IL2RA相關的疾病；在維基數據上查看/編輯參考. 
2. GRCh38: Ensembl release 89: ENSG00000134460 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000026770 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
6. Spolski R, Li P, Leonard WJ. Biology and regulation of IL-2: from molecular mechanisms to human therapy. Nature Reviews. Immunology. October 2018, 18 (10): 648–659. PMID 30089912. S2CID 51939991. doi:10.1038/s41577-018-0046-y. 
7. Zhou P. Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity. Cytokine & Growth Factor Reviews. October 2022, 67: 80–88. PMID 35803833. S2CID 250200065. doi:10.1016/j.cytogfr.2022.06.003. 

外部链接

• 醫學主題詞表（MeSH）：Interleukin-2+Receptors