zh HLA-B

HLA-B
已知的結構
PDB	人类UniProt搜索: PDBe RCSB
PDBID列表
	3VCL、4U1H、4U1K、5EO1、5EO0,%%s1AGB、1AGC、1AGD、1AGE、1AGF、1M05、1MI5、3FFC、3SJV、3SKM、3SKO、3SPV、3X13、3X14、4QRP、4QRQ、4QRS、4QRT、4QRU,%%s4O2C、4O2E、4O2F,%%s3LN4、3LN5,%%s4U1J、4U1M、4U1N,%%s4U1I、4U1L、4U1S,%%s1HSA、1JGD、1JGE、1K5N、1OF2、1OGT、1UXS、1UXW、1W0V、1W0W、2A83、2BSR、2BSS、2BST、3B3I、3B6S、3BP4、3BP7、3CZF、3D18、3DTX、3HCV、3LV3、4G8G、4G8I、4G9D、4G9F、5DEF、5DEG,%%s1A1N、1A9B、1A9E、1CG9、1XH3、1ZHK、1ZHL、1ZSD、2AK4、2AXF、2AXG、2H6P、2NW3、2NX5、3BW9、3BWA、3KWW、3KXF、3LKN、3LKO、3LKP、3LKQ、3LKR、3LKS、3MV7、3MV8、3MV9、3VFS、3VFT、3VFU、3VFV、3VFW、4LNR、4PR5、4PRN、4QRR,%%s1A1M、1A1O,%%s2BVO、2BVP、2BVQ、2HJL、2RFX、2YPK、2YPL、3UPR、3VH8、3VRI、3VRJ、3WUW、3X11、3X12、5B39、5B38,%%s4JQV、4XXC,%%s1XR8、1XR9、3C9N,%%s4LCY,%%s1M6O、1N2R、1SYV、3DX6、3DX7、3DX8、3DXA、3KPL、3KPM、3KPN、3KPO、3KPP、3KPQ、3KPR、3KPS、3L3D、3L3G、3L3I、3L3J、4JQX,%%s1E27、1E28、4MJI,%%s3W39
識別號
别名	HLA-B；, AS, SPDA1, Bw-47, Bw-50, major histocompatibility complex, class I, B, B-4901, B-5001, HEL-S-83, HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1
外部ID	HomoloGene：134029 GeneCards：HLA-B
相關疾病
	人类免疫缺陷病毒传染性疾病
基因位置（人类）
染色体	6號染色體
终止	31,367,067 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• signaling receptor binding; • peptide antigen binding;
細胞組分	• integral component of membrane; • phagocytic vesicle membrane; • 高尔基体; • early endosome membrane; • 膜; • Golgi membrane; • 细胞膜; • integral component of plasma membrane; • cell surface; • 内质网; • MHC class I protein complex; • ER to Golgi transport vesicle membrane; • integral component of lumenal side of endoplasmic reticulum membrane; • 外排體; • secretory granule membrane; • recycling endosome membrane;
生物學過程	• antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • regulation of interleukin-12 production; • interferon-gamma-mediated signaling pathway; • immune system process; • antigen processing and presentation of peptide antigen via MHC class I; • regulation of dendritic cell differentiation; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; • protection from natural killer cell mediated cytotoxicity; • type I interferon signaling pathway; • 免疫反应; • regulation of immune response; • regulation of T cell anergy; • viral process; • regulation of interleukin-6 production; • neutrophil degranulation;
	Sources:Amigo / QuickGO
直系同源
	3106
	无数据
ENSG00000228964; ENSG00000234745; ENSG00000206450; ENSG00000224608; ENSG00000223532;
	ENSG00000232126
	无数据
	P01889
	无数据
	NM_005514
	无数据
	NP_005505
	无数据
	維基數據
檢視/編輯人類

HLA-B是人類白細胞抗原（HLA）的一个基因座，位于6号染色体上。

参考文献

^ 與HLA-B相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000228964、ENSG00000234745、ENSG00000206450、ENSG00000224608、ENSG00000223532、ENSG00000232126 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

延伸阅读

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Tassaneeyakul W, Tiamkao S, Jantararoungtong T, Chen P, Lin SY, Chen WH, Konyoung P, Khunarkornsiri U, Auvichayapat N, Pavakul K, Kulkantrakorn K, Choonhakarn C, Phonhiamhan S, Piyatrakul N, Aungaree T, Pongpakdee S, Yodnopaglaw P. Association between HLA-B*1502 and carbamazepine–induced severe cutaneous adverse drug reactions in a Thai population. Epilepsia. 2010, 51 (5): 926–30. PMID 20345939. doi:10.1111/j.1528-1167.2010.02533.x. Full text(PDF)（页面存档备份，存于互联网档案馆）

This article incorporates public domain text from The U.S. National Library of Medicine（页面存档备份，存于互联网档案馆）

外部链接

[1] 與HLA-B相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000228964、ENSG00000234745、ENSG00000206450、ENSG00000224608、ENSG00000223532、ENSG00000232126 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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