阿来司酮

阿来司酮
臨床資料
商品名（英语：Drug nomenclature）Alizin
其他名稱安哥司酮、RU-46534、RU-534
藥物類別（英语：Drug class）抗孕激素（英语：Antiprogestogen）、抗糖皮质激素（英语：Antiglucocorticoid）
ATC碼
识别信息
  • (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS号124478-60-0
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
ECHA InfoCard100.211.372 編輯維基數據鏈接
化学信息
化学式C29H37NO2
摩尔质量431.62 g·mol−1
3D模型（JSmol（英语：JSmol））
  • C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
  • InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
  • Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N

阿来司酮（INN：aglepristone；开发代号：RU-46534、RU-534），或译安哥司酮，是一种与米非司酮相关的合成类甾体抗孕激素（英语：Antiprogestogen），由维克（英语：Virbac）在几个欧洲国家销售，用作兽药。[1][2][3]它专门用作妊娠动物的堕胎药（英语：Abortifacient）。[1][3][4]阿来司酮也具有一些抗糖皮质激素（英语：Antiglucocorticoid）活性。[5][6]

参考资料

  1. ^ 1.0 1.1 Kaufman LK, Baldwin CJ. Pregancy Loss in the Bitch and Queen. Bonagura JD, Twedt DC (编). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. 1 December 2013: 3009–. ISBN 978-0-323-22762-9. 
  2. ^ Squires EJ. Endocrine manipulation of reproduction.. Applied Animal Endocrinology. CABI. 2010: 207–. ISBN 978-1-84593-755-3. 
  3. ^ 3.0 3.1 Papich MC. Aglepristone. Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. 3 November 2010: 120–. ISBN 978-1-4377-0192-0. 
  4. ^ Fieni F, Martal J, Marnet PG, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D. Concannon PW , 编. Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534). Journal of Reproduction and Fertility. Supplement. Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000. 2001, 57: 243–8. ISBN 978-0-906545-37-9. PMID 11787157. 
  5. ^ Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. Induction of parturition with aglepristone in the Majorera goat. Reproduction in Domestic Animals = Zuchthygiene. October 2011, 46 (5): 882–888. PMID 21320179. doi:10.1111/j.1439-0531.2011.01759.x. 
  6. ^ Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC. Hormonal changes in spontaneous and aglépristone-induced parturition in dogs. Theriogenology. March 2008, 69 (4): 399–407. PMID 18054071. doi:10.1016/j.theriogenology.2007.10.008.