vi FCGR2A

FCGR2A
Cấu trúc được biết đến
PDB	Tìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB
	1FCG, 1H9V, 3D5O, 3RY4, 3RY5, 3RY6
Mã định danh
Danh pháp	FCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
ID ngoài	OMIM: 146790 HomoloGene: 47936 GeneCards: FCGR2A
Mẫu hình biểu hiện RNA
	; ; ; ;
	Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen
Chức năng phân tử	• GO:0001948, GO:0016582 protein binding; • IgG binding;
Thành phần tế bào	• integral component of membrane; • Màng tế bào; • membrane; • secretory granule membrane; • Vách tế bào;
Quá trình sinh học	• Fc-gamma receptor signaling pathway involved in phagocytosis; • immune system process; • neutrophil degranulation; • cell adhesion;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	2212
	n/a
	ENSG00000143226
	n/a
	P12318
	n/a
	NM_001136219; NM_021642; NM_001375296; NM_001375297
	n/a
	NP_001129691; NP_067674; NP_001362225; NP_001362226
	n/a
	Wikidata
Xem/Sửa Người

Low affinity immunoglobulin gamma Fc region receptor II-a là protein ở người được mã hóa bởi gen FCGR2A.^[2]^[3]

Tương tác

FCGR2A có khả năng tương tác với PIK3R1^[4]^[5] và Syk.^[5]^[6]

Xem thêm

CD32

Tham khảo

^ “Human PubMed Reference:”.
^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (tháng 6 năm 1990). “Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination”. Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
^ “Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)”.
^ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (tháng 5 năm 1996). “Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides”. J. Biol. Chem. UNITED STATES. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
^ ^a ^b Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (tháng 7 năm 1997). “Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa”. Biochim. Biophys. Acta. NETHERLANDS. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
^ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (tháng 1 năm 2001). “Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis”. Clin. Immunol. UNITED STATES. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.

Đọc thêm

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Chacko GW, Brandt JT, Coggeshall KM, Anderson CL (1996). “Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides”. J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. PMID 8631888.
Salmon JE, Millard S, Schachter LA, và đồng nghiệp (1996). “Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans”. J. Clin. Invest. 97 (5): 1348–54. doi:10.1172/JCI118552. PMC 507190. PMID 8636449.
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Ibarrola I, Vossebeld PJ, Homburg CH, và đồng nghiệp (1997). “Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa”. Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. PMID 9268059.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, và đồng nghiệp (1997). “Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
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