ABSTRACTAim: to evaluate treatment trend of stage T3 prostate cancer based on several factors. Methods: a retrospective studywas done on stage T3 prostate cancer patients from year 1995-2013, at two national referral hospitalsin Indonesia.Treatment trends between hormonal therapy and radiotherapy based on year of treatment, PSA level, tumor grade andage groups were evaluated.Results: On 50 patients subjects, 25 (50%), 23 (46%) and 2 (4%) subjects were treated byradiotherapy, hormonal therapy and radical prostatectomy, respectively. Year of treatment were significantly associatedwith treatment selection (p=0.012), after excluding year of treatment 1995-1999 group. Hormonal therapy was preferredon high grade tumor group (53.8%) and more applied for older patients. Treatment trend was not affected by PSA level.Conclusion: Year of treatment were significantly associated with treatment selection of stage T3 prostate cancer.Hormonal therapy was preferred on high grade tumor group and older age groups.Keyword: treatment trend, locally advanced prostate cancer, radiotherapy, hormonal therapyABSTRAKPenelitian ini bertujuan mengevaluasi tren tata laksana kanker prostat stage T3 berdasarkan faktor-faktor yangmemengaruhi. Metode: studi retrospektif tata laksana kanker prostat stage T3 di Rumah Sakit Cipto Mangunkusumodan Rumah Sakit Kanker “Dharmais” periode 1995-2013. Data tren pemilihan terapi antara radioterapi atau terapihormonal dianalisis berdasarkan kelompok tahun terapi, kadar PSA, grade tumor, dan kelompok usia. Hasil penelitianmenunjukkan dari 50 subjek, 25 (50%), 23 (46%), dan 2 (4%) subjek mendapatkan tata laksana radioterapi, terapihormonal, dan prostatektomi radikal secara berturutan. Perubahan tren pemilihan terapi berdasarkan tahun terapisecara statistik signifikan (p=0,012), dengan mengeksklusikan kelompok periode terapi 1995-1999. Terapi hormonallebih menjadi pilihan untuk kelompok tumor high grade (53,8%) dan lebih sering dipilih seiring bertambahnya usiapasien. Kadar PSA tidak memengaruhi tren pemilihan terapi. Kesimpulan: terdapat perubahan yang bermakna dalampemilihan terapi kanker prostat stage T3 berdasarkan tahun terapi. Terapi hormonal lebih menjadi pilihan pada kasusdengan tumor high grade dan kelompok usia yang semakin tua.Kata Kunci: tren terapi, kanker prostat lokal lanjut, radioterapi, terapi hormonal

Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)
Journal Name Indonesian Journal of Cancer
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Location Kota adm. jakarta barat, Dki jakarta INDONESIA
Website ijoc| http://www.indonesianjournalofcancer.or.id/e-journal|
ISSN ISSN : 19783744, EISSN : 23556811, DOI : -,
Core Subject Health,
Meta Subject Health Professions,
Meta DescThe Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.
PenulisIRDAM, GAMPO ALAM
Publisher Article"Dharmais" Cancer Center Hospital
Subtitle Article Indonesian Journal of Cancer Vol 9, No 1 (2015): Jan - Mar 2015
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