Background : Alum was in the form of white crystals and gelatin used in the water purification process, but there was still many misuses as a food coloring and food preservatives. Alum has the harmful side effects to the body, especially hepar as an organ that plays a role in the metabolism and detoxification.Aim : To determined differences in hepar histopathology wistar rats of alum exposure with graded dosages for 30 days.Metods : This was an experimental laboratoric research study design with a post test only control group design. There were 20 wistar rats, which have met the inclusion and exclusion criteria and adapted for 7 days. Then, wistar rats devided by simple random sampling into 4 groups. The control group (C) who were given only standard food and bevarages, group P1 given alum in feed 2400mg/kg body weight/day, group P2 given alum in feed 1600mg/kg body weight/day, and group P3 given alum in feed 800mg/kg body weight/day. After 30 days, histopathological examinated of hepar form degeneration and inflammation. Data described on the tabel, picture, and statistic analyze.Result : Mean of inflammation and degeneration hepar cell was the biggest in the group of P1. In inflammation, there was significant difference (p<0,05) in the group of C-P1, C-P2, C-P3, P1-P3, and P2-P3, although P1-P2 was not significant difference. In degeneration of hepar cell, there was significant difference (p<0,05) in the group of C-P1, C-P2, C-P3, P1-P3, and P2-P3, although P1-P2 was not significant difference.Conclusion : Giving alum in feed with graded dosage for 30 days cause change of wistar rats hepar histopathology.
| Published by | Universitas Diponegoro |
| Journal Name | Jurnal Kedokteran Diponegoro |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kota semarang, Jawa tengah INDONESIA |
| Website | medico| https://ejournal3.undip.ac.id/index.php/medico| |
| ISSN | ISSN : -, EISSN : 25408844, DOI : -, |
| Core Subject | Health, |
| Meta Subject | Medicine & Pharmacology, |
| Meta Desc | JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang. |
| Penulis | Ananda, Putri Rizki , Ismail, Akhmad |
| Publisher Article | DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) |
| Subtitle Article | DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 5, No 3 (2016): JURNAL KEDOKTERAN DIPONEGORO |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://ejournal3.undip.ac.id/… |
| DOI | http://download.garuda.ristekdikti.… |
| DOI Number | Full PDF (346.409 KB) |
| Download Article [1] | https://ejournal3.undip.ac.id/index.php/… |
| Download Article [2] | http://download.garuda.ristekdikti.go.id… |
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