Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that are often associated with uneffectiveness of the BCG vaccine and the high worm infection. The objective of this study was to determine the differences in the activity of Limfosit T type Th1 (IFN-g) and Th2 (IL-4) in lung tissue on Heligmosomoides polygyrus nematode and Mycobacterium tuberculosis sequential co-infection. This research using 49 mice were divide into 7 groups treated with infection by Mycobacterium tuberculose inhaled and Heligmosomoides polygyrus orally within 8 and 16 weeks. The levels of IFN-g in peripheral blood serum (89.929 + 3.533 pg/mL) resembles the pattern of the percentage of lymphocytes T CD4+ Th1 in lung tissue (3.246 + 0.519%) and peripheral blood (4.950 + 0.237%), while the levels IL-4 in the peripheral blood serum (20.782 + 4.043%) resembles the pattern of the percentage of lymphocytes T CD4+ Th2 in intestinal tissue (1.048 + 0.359%) and peripheral blood (1.196 + 0.557%). In conclusion, there is difference in the activity of lymphocytes T type Th1 and Th2 but it does not affect the immune response to Mycobacterium tuberculosis infection.
| Published by | Universitas Airlangga |
| Journal Name | Folia Medica Indonesiana |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kota surabaya, Jawa timur INDONESIA |
| Website | FMI| https://e-journal.unair.ac.id/index.php/FMI| |
| ISSN | ISSN : 23558393, EISSN : 2599056X, DOI : -, |
| Core Subject | Education, |
| Meta Subject | Other, |
| Meta Desc | Folia Medica Indonesiana publishes articles in the field of medical science in particular and health sciences in general, as well as a variety of other fields related to those two disciplines. Most of the articles are research article, and others are articles on case reports and literature review. In their presentation in the journal, the articles have passed meticulous editing process by the editors and review process and by competent peer reviewers, with national and international reputation, making the articles presented in this journal qualified, updated, and informative. |
| Penulis | Wulandari, Laksmi , Amin, Muhammad , Soedarto, Soedarto , Soegiarto, Gatot |
| Publisher Article | Faculty of Medicine, Universitas Airlangga |
| Subtitle Article | Folia Medica Indonesiana Vol 53, No 2 (2017): JUNE 2017 |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | http://e-journal.unair.ac.id/F… |
| DOI | https://doi.org/10.20473/fmi.v53i2.… |
| DOI Number | DOI: 10.20473/fmi.v53i2.6356 |
| Download Article [1] | http://e-journal.unair.ac.id/FMI/article… |
| Download Article [2] | http://download.garuda.ristekdikti.go.id… |
Informasi yang terkait dengan LYMPHOCYTE T TYPE TH1 AND TH2 ACTIVITY DIFFERENCE OF LUNG TISSUE ON Heligmosomoides polygyrus NEMATODE AND Mycobacterium tuberculosis SEQUENTIAL CO INFECTION