Patients with end-stage kidney disease (ESRD) undergoing hemodialysis (HD) tend to have multiple comorbidities, especially cardiovascular disease, mineral and bone disorders which are important factors and contribute to the morbidity and mortality of HD patients. So it is important to know the types of intra-dialysis physical exercises that are safe and effective for HD patients. The type of research analyzed in this journal writing is a randomized controlled trial (RCT) that focuses on inter-dialysis physical exercise interventions both at home and HD center. With a literature search using PubMed, ScienceDirect, Willey, Proquest and Google Scholar databases. And those who meet the relevant requirements and reviews are: 8. Based on several reviews of intradialytic exercise studies in HD patients, intra-dialysis low intensity strength training is found safe and effective in adults and older. Research shows that doing 30 minutes of intradialytic exercise per session 3 times a week for at least ≥8 weeks is beneficial for HD patients. Regular exercise should be considered as an important therapeutic modality in the care of patients undergoing HD. Strength training improves physical performance, nutritional status and physical activity. But this study needs further research, so that it can contribute to the provision of evidence-based information in applying safe intradialytic exercises and become part of routine dialysis treatment units

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