Background: Infection with Helicobacter pylori (HP) estimated to occur in 50% of the population in the world. Helicobacter pylori infection causes inflammation of the gastric mucosa and gastric epithelial release of interleukin-1β, interleukin-6, interleukin-8 and tumor necrosis factor α. Interleukin-8 plays a role in the degree of chronic inflammation of the gastric mucosa and gastric cancer risk. There has been no research on differences in the expression of interleukin-8 is based on chronic and chronic active inflammation on biopsy of the gastric mucosa with Helicobacter pylori infection in Hospital Dr. Sardjito.Objective: To prove the differences in the expression of interleukin-8 of chronic inflammation and gastric mucosal biopsy active chronic infection with Helicobacter pylori.Methods: This study used a cross-sectional design. Examined the expression of interleukin-8 on the rest of the biopsy sample HP (+) in August 2009 to March 2014. Classification of chronic inflammatory and chronic active obtained through histopathology report. Categorical numerical data from the two groups, unpaired, the distribution is not normal: Mann-Whitney test. Differences were considered significant if it was obtained p <0.05 with a confidence interval of 95%.Results: There were 41 samples of gastric mucosa biopsy preparations, comprising 9 samples of chronic inflammation and 32 samples of chronic inflammatory active of the gastric mucosa. The median value of the expression of IL-8 eptitel surface on chronic inflammation by 83 (40-94)% and the active chronic inflammation by 82 (19-94). Comparison test with Mann Whitney U test. From the statistical calculations p value = 0.887 with p> 0.05Conclusion: There is no difference in the expression of interleukin-8 in inflammatory chronic active and chronic inflammation of the gastric mucosa with Helicobacter pylori infection.Keywords: Helicobacter pylori, interleukin-8, chronic inflammation and chronic inflammatory active.
| Published by | Universitas Gadjah Mada |
| Journal Name | Jurnal Acta Interna |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kab. sleman, Daerah istimewa yogyakarta INDONESIA |
| Website | jain| https://journal.ugm.ac.id/index.php/jain| |
| ISSN | ISSN : 2303131X, EISSN : 25415441, DOI : -, |
| Core Subject | Health, |
| Meta Subject | Health Professions, Medicine & Pharmacology, |
| Meta Desc | The Journal considers any original research that advocates change in, or illuminates, clinical practice. The journal also publishes interesting and informative reviews and opinions pieces on any topics connected with clinical practice. Manuscripts must be solely the work of the author(s) stated, not have been published previously elsewhere, and not be under consideration by another journal. all papers should be written to be clearly understandable to the journal`s readers in a wide range of specialities and countries. Diagrams, figures, and photographs should be used to supplement and enhance the text. |
| Penulis | Arif, Muhammad , Nurdjanah, Siti , Ratnasari, Neneng |
| Publisher Article | Faculty of Medicine Universitas Gadjah Mada |
| Subtitle Article | Acta Interna The Journal of Internal Medicine Vol 7, No 1 (2017): Acta Interna The Journal of Internal Medicine |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://journal.ugm.ac.id/jain… |
| DOI | https://doi.org/10.22146/actaintern… |
| DOI Number | DOI: 10.22146/actainterna.48161 |
| Download Article [1] | https://journal.ugm.ac.id/jain/article/d… |
| Download Article [2] | http://download.garuda.ristekdikti.go.id… |
Informasi yang terkait dengan Interleukin 8 expression differences in chronic and active chronic inflammation gastric mucosa biopsy with helicobacter pylori infection
Interleukin Interleukin-2 Interleukin-6 Interleukin-10 Interleukin-3 Interleukin-18 Interleukin 12 Interleukin-15 Interleukin-5 Interleukin-4 Interleukin-13 Interleukin-1 Interleukin-8