ABSTRACTBackground: Insulin sensitizer drugs such as metformin has suggested giving in metabolic syndrome patient and NAFLD, which both pathogeneses were insulin resistance. Angiotensin II receptor blocker (ARB), anti-hypertension drugs, has the similar properties to improve regulation of Proliferator-Activated Receptor Gama (PPARɤ). This aim of the study is to prove the improvement of insulin resistance which examined by HOMA-IR method on metabolic syndrome patient with NAFLD after receiving metformin and valsartan medication.Method: This study was conducted to the patient in Endocrinology Clinic Sardjito General Hospital aged 35-36 years who meet diagnostic criteria for metabolic syndrome based on the IDF in 2006 and NAFLD. Convenience sampling method is done for 11 months (May 2012 – March 2013) and was expected sample size 35. HOMA-IR examination made before and after administration of metformin and valsartan for 12 weeks. Cut off value for HOMA –IR on pathological metabolic syndrome and NAFLD was ≥ 2. Medical and Health Research Ethics Committee (MHREC) Faculty of Medicine Universitas Gadjah Mada approved this study protocol.Result: Subject of study retrieved 15 (43%), six males (40%) and nine females (60%) aged 43-63 years old. Median HOMA-IR baseline was 2.8 (0.6-14.5) and at the end of therapy was 3.8 (1.72-14.1). Eleven (74%) have increased HOMA-IR value and four (26%) experience declined but none of them reach the value below 2. In general clinical improvement occurs in the form of AST and ALT reduction but not statistically significant.Conclusion: This study does not prove that administration of metformin and valsartan in-patient with metabolic syndrome with NAFLD would improve insulin resistance assessed by the HOMA-IR method.Keywords: Metformin, valsartan, metabolic syndrome, NAFLD, HOMA-IR 

Informasi yang terkait dengan Effect of Metformin and Valsartan Toward Homa IR in Metabolic Syndrome Patient with Non Alcoholic Fatty Liver Disease (NAFLD)

Mass Effect Mass Effect: Andromeda The Twins Effect Mass Effect 3 Mass Effect Galaxy Mass Effect (permainan video) The Twins Effect II The Lazarus Effect (film 2015) Rain Effect The Butterfly Effect The Butterjunk Effect Chilling effect The Autumn Effect The Butterfly Effect (Heroes) Hard–easy effect The Warp Effect Hall effect sensor The First Step: Treasure Effect Efek lintas ras James while John had had had had had had had had had had had a better effect on the teacher Efek Jokowi Pengaruh Coandă Derren Brown SpongeBob SquarePants (musim 3) Kilau (mineralogi)