Background: Stress that is induced by sleep deprivation can modulate the damage of periodontal tissue by elevating the levels of proinflammatory cytokines (i.e. IL-1? and TNF-?). The effects of sleep deprivation can be resolved with sleep recovery. Gingival crevicular fluid (GCF) is fluid in sulcular gingiva which acts as an oral biomarker for evaluating periodontal abnormalities. Purpose: The aim of this study was to determine the effect of various induction methods of sleep deprivation stress on cytokine levels in GCF of white male Wistar strain rats (Rattus novergicus). Methods: The study method was true experimental with a posttest-only control group design. Thirty male Wistar rats were randomly divided into five groups: paradoxical sleep deprivation (PSD), total sleep deprivation (TSD), partial sleep deprivation with sleep recovery for five days (PSD+SR), total sleep deprivation with sleep recovery for five days (TSD+SR) and a healthy control group. Data were analysed via one-way ANOVA to determine differences between groups. Result: The results showed the highest level of IL-1? and TNF-? was found in the PSD group. One-way ANOVA analysis showed significant differences (p<0,05) of IL-1? level between PSD and control groups, PSD and PSD+SR groups and PSD and TSD+SR groups; in contrast, the analysis of TNF-? levels showed significant differences (p<0,05) between PSD group to control group, PSD to PSD+SR group and TSD to TSD+SR group. Conclusions: There is an effect of various induction methods of sleep deprivation stress on proinflammatory cytokines (IL-1? and TNF-?).
| Published by | Universitas Airlangga |
| Journal Name | Dental Journal (Majalah Kedokteran Gigi) |
| Contact Phone | - |
| Contact Name | Saka Winias |
| Contact Email | saka.winias@gmail.com |
| Location | Kota surabaya, Jawa timur INDONESIA |
| Website | MKG| https://e-journal.unair.ac.id/index.php/MKG| |
| ISSN | ISSN : 19783728, EISSN : 24429740, DOI : -, |
| Core Subject | Health, |
| Meta Subject | Dentistry, |
| Meta Desc | The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. |
| Penulis | Widyaningsih, Pratiwi Nur , Arjadi, Fitranto , Mahanani, Erlina Sih |
| Publisher Article | Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en |
| Subtitle Article | Dental Journal (Majalah Kedokteran Gigi) Vol 53, No 1 (2020): (March 2020) |
| Scholar Google | http://scholar.google.com/scholar?q=%2Bintitle%3A&… |
| View Article | https://e-journal.unair.ac.id/… |
| DOI | https://doi.org/10.20473/j.djmkg.v5… |
| DOI Number | DOI: 10.20473/j.djmkg.v53.i1.p24-29 |
| Download Article [1] | https://e-journal.unair.ac.id/MKG/articl… |
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